{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:42:59Z","timestamp":1790937779916,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T00:00:00Z","timestamp":1389571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate if delays in resting\u2010state spontaneous fluctuations of the BOLD (sfBOLD) signal can be used to create maps similar to time\u2010to\u2010maximum of the residue function (Tmax) in Moyamoya patients and to determine whether sfBOLD delays affect the results of brain connectivity mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ten patients were scanned at 3 Tesla using a gradient\u2010echo echo planar imaging sequence for sfBOLD imaging. Cross correlation analysis was performed between each brain voxel signal and a reference signal comprised of either the superior sagittal sinus (SSS) or whole brain (WB) average time course. sfBOLD delay maps were created based on the time shift necessary to maximize the correlation coefficient, and compared with dynamic susceptibility contrast Tmax maps. Standard and time\u2010shifted resting\u2010state BOLD connectivity analyses of the default mode network were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Good linear correlations were found between sfBOLD delays and Tmax using the SSS as reference (r<jats:sup>2<\/jats:sup>\u2009=\u20090.8, slope\u2009=\u20091.4, intercept\u2009=\u2009\u22124.6) or WB (r<jats:sup>2<\/jats:sup>\u2009=\u20090.7, slope\u2009=\u20090.8, intercept\u2009=\u2009\u22123.2). New nodes of connectivity were found in delayed regions when accounting for delays in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Resting\u2010state sfBOLD imaging can create delay maps similar to Tmax maps without the use of contrast agents in Moyamoya patients. Accounting for these delays may affect the results of functional connectivity maps. <jats:bold>J. Magn. Reson. Imaging 2015;41:424\u2013430.<\/jats:bold>\u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24558","type":"journal-article","created":{"date-parts":[[2014,1,13]],"date-time":"2014-01-13T15:06:43Z","timestamp":1389625603000},"page":"424-430","source":"Crossref","is-referenced-by-count":98,"title":["Noncontrast mapping of arterial delay and functional connectivity using resting\u2010state functional MRI: A study in Moyamoya patients"],"prefix":"10.1002","volume":"41","author":[{"given":"Thomas","family":"Christen","sequence":"first","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesamoddin","family":"Jahanian","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy W.","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Moseley","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Zaharchuk","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California 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