{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:29:15Z","timestamp":1760984955341,"version":"3.40.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Elevated cerebral blood flow (CBF) in sickle cell anemia (SCA) is an adaptive pathophysiologic response associated with decreased vascular reserve and increased risk for ischemia. We compared manual (M) and semiautomated (SA) vascular territory delineation to facilitate standardized evaluation of CBF in children with SCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>ASL perfusion values from 21 children were compared for gray matter and white matter (WM) in vascular territories defined by M and SA delineation. SA delineated CBF was compared with clinical and hematologic variables acquired within 4 weeks of the MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CBF measurements from M (MCA 82 left, 79 right) and SA (MCA 81 left, 81 right) delineated territories were highly correlated (R\u2009=\u20090.99,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Bland\u2010Altman plots had close\u2010fitting limits of agreement of \u22121.8 to \u22123.5 lower limit and 0 to 1.8 upper limit. SA vascular territory delineation was comparable to the expert delineation with a kappa index of 0.62\u20130.85 and was considerably faster. Median territorial CBF values did not differ by gender or age. WM perfusion in the posterior cerebral artery territories was positively correlated with degree of hemolysis (R\u2009=\u20090.58,<jats:italic>P<\/jats:italic>\u2009=\u20090.01 left, 0.73,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 right) and negatively correlated with hemoglobin (R\u2009=\u2009\u22120.48;<jats:italic>P<\/jats:italic>\u2009=\u20090.03 left; \u22120.47;<jats:italic>P<\/jats:italic>\u2009=\u20090.04 right) and hemoglobin F (R\u2009=\u2009\u22120.42;<jats:italic>P<\/jats:italic>\u2009=\u2009.09 left; \u22120.47;<jats:italic>P<\/jats:italic>\u2009=\u20090.049 right).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We established the validity of the SA method, which in our experience was much faster than the M method for delineation of vascular territories. Associations between CBF and hematologic variables may demonstrate pathophysiologic changes that contribute to clinical variation in CBF.<jats:bold>J. Magn. Reson. Imaging 2015;41:439\u2013446.<\/jats:bold>\u00a9<jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24559","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T06:16:51Z","timestamp":1389161811000},"page":"439-446","source":"Crossref","is-referenced-by-count":9,"title":["Comparing segmented ASL perfusion of vascular territories using manual versus semiautomated techniques in children with sickle cell anemia"],"prefix":"10.1002","volume":"41","author":[{"given":"Kathleen J.","family":"Helton","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John O.","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilburn E.","family":"Reddick","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Paydar","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash R.","family":"Zandieh","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachna","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Smeltzer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu","family":"Aygun","sequence":"additional","affiliation":[{"name":"Department of Hematology St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Ogg","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences St Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12413"},{"key":"e_1_2_6_3_1","first-page":"965","article-title":"The spectrum of brain MR abnormalities in sickle\u2010cell disease: a report from the Cooperative Study of Sickle Cell Disease","volume":"17","author":"Moser FG","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2281020943"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800206"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.562"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2272020903"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23505"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.523308"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21745"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.3.344"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-011-9133-4"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2006.00507.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1246::AID-MRM22>3.0.CO;2-N"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1699"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.09.012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.650887"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20259"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","DOI":"10.1055\/b-002-56129","volume-title":"Cranial neuroimaging and clinical neuroanatomy: atlas of MR imaging and computed tomography","author":"Kretschmann HJ","year":"2004"},{"volume-title":"The Brain atlas, a visual guide to the human central nervous system","year":"2003","author":"Woolsey TA","key":"e_1_2_6_23_1"},{"key":"e_1_2_6_24_1","first-page":"130","volume-title":"Diagnostic neuroradiology","author":"Osborn AG","year":"1994"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02283018"},{"volume-title":"Radiology assistant","year":"2008","author":"Smithuis R","key":"e_1_2_6_26_1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"e_1_2_6_28_1","first-page":"787","volume-title":"Nonparametric statistical methods","author":"Hollander M","year":"1999"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2307\/2987937"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10192"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.4.692"},{"key":"e_1_2_6_33_1","first-page":"71","article-title":"Cerebral vasculopathy in sickle cell anemia: diagnostic contribution of positron emission tomography","volume":"93","author":"Powars DR","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.2.8475289"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10372"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10416"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057893"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20839"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20023"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.2.183"},{"key":"e_1_2_6_41_1","first-page":"462","article-title":"Effects of normal aging, sex and risk factors for stroke on regional cerebral blood flow (rCBF) in normal volunteers","author":"Shaw T","year":"1979","journal-title":"Acta Neurol Scand"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S14942"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00611.2009"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.24559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.24559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:41:59Z","timestamp":1746099719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.24559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/jmri.24559"],"URL":"https:\/\/doi.org\/10.1002\/jmri.24559","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"type":"print","value":"1053-1807"},{"type":"electronic","value":"1522-2586"}],"subject":[],"published":{"date-parts":[[2014,1,8]]}}}