{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:14:40Z","timestamp":1761059680257},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the feasibility of T1rho mapping of menisci at 3T in discriminating between patients with acute anterior cruciate ligament (ACL) injury and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010three subjects were included in the study and subdivided into two subgroups: 16 healthy controls (4 females, 12 males; mean age\u2009=\u200934.4\u2009\u00b1\u200910.2 years, age range 24\u201363 years), 17 patients with ACL injury (3 females, 14 males; mean age\u2009=\u200929.8\u2009\u00b1\u200910.8 years, age range 18\u201361 years). T1rho images from all subjects were acquired on a 3T MR scanner using a spin\u2010lock\u2010based 3D GRE sequence and computed for T1rho mapping. Clinical proton density (PD)\u2010weighted fast spin echo (FSE) images in the sagittal (without fat saturation), axial, and coronal (fat\u2010saturated) planes were also acquired for cartilage assessment using Whole\u2010Organ MR Imaging Score (WORMS) grading. Mixed model two\u2010way analysis of variance (ANOVA) was performed to determine whether there were any significant differences among subregional, compartmental, and whole structure T1rho values of meniscus between healthy controls and ACL\u2010injured patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lateral posterior (29\u2009\u00b1\u20098 msec) and medial central (25\u2009\u00b1\u20097 msec) meniscus subregions in healthy controls had significantly lower T1rho values (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) than the corresponding meniscus subregions in ACL\u2010injured patients. Significantly lower meniscus T1rho values (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were also identified in lateral compartment in healthy controls (26\u2009\u00b1\u20096 msec) than that of ACL\u2010injured patients (33\u2009\u00b1\u20094 msec). Subjects' total WORMS between healthy controls and ACL\u2010injured patients had significant differences (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary results indicate that T1rho mapping is possibly feasible in detecting meniscus degeneration and may be useful in distinguishing ACL\u2010injured patients. <jats:bold>J. Magn. Reson. Imaging 2015;41:544\u2013549.<\/jats:bold>\u00a9 <jats:bold>2013 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24594","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T08:02:44Z","timestamp":1393401764000},"page":"544-549","source":"Crossref","is-referenced-by-count":15,"title":["T1rho MRI at 3T of menisci in patients with acute anterior cruciate ligament (ACL) injury"],"prefix":"10.1002","volume":"41","author":[{"given":"Ligong","family":"Wang","sequence":"first","affiliation":[{"name":"Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG) Center for Biomedical Imaging Department of Radiology New York, University Langone Medical Center New York NY USA"},{"name":"School of Radiation Medicine and Protection Medical College of Soochow University; School for Radiological and Interdisciplinary Sciences (RAD\u2010X), Soochow University Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Chang","sequence":"additional","affiliation":[{"name":"Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG) Center for Biomedical Imaging Department of Radiology New York, University Langone Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Bencardino","sequence":"additional","affiliation":[{"name":"Hospital for Joint Diseases New York University Langone Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Babb","sequence":"additional","affiliation":[{"name":"Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG) Center for Biomedical Imaging Department of Radiology New York, University Langone Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Rokito","sequence":"additional","affiliation":[{"name":"Hospital for Joint Diseases New York University Langone Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laith","family":"Jazrawi","sequence":"additional","affiliation":[{"name":"Hospital for Joint Diseases New York University Langone Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orrin","family":"Sherman","sequence":"additional","affiliation":[{"name":"Hospital for Joint Diseases New York University Langone Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder R.","family":"Regatte","sequence":"additional","affiliation":[{"name":"Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG) Center for Biomedical Imaging Department of Radiology New York, University Langone Medical Center New York NY 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