{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:27:35Z","timestamp":1790051255633,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:00:00Z","timestamp":1397174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["KU1329\/10-1"],"award-info":[{"award-number":["KU1329\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To reduce the need for diagnostic catheterization and optimize treatment in a variety of congenital heart diseases, magnetic resonance imaging (MRI)\u2010based computational fluid dynamics (CFD) is proposed. However, data about the accuracy of CFD in a clinical context are still sparse. To fill this gap, this study compares MRI\u2010based CFD to catheterization in the coarctation of aorta (CoA) setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirteen patients with CoA were investigated by routine MRI prior to catheterization. 3D whole\u2010heart MRI was used to reconstruct geometries and 4D flow\u2010sensitive phase\u2010contrast MRI was used to acquire flows. Peak systolic flows were simulated using the program FLUENT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peak systolic pressure drops in CoA measured by catheterization and CFD correlated significantly for both pre\u2010 and posttreatment measurements (pre: <jats:italic>r<\/jats:italic>\u2009=\u20090.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.00; post: <jats:italic>r<\/jats:italic>\u2009=\u20090.87, <jats:italic>p<\/jats:italic>\u2009=\u20090.00). The pretreatment bias was \u22120.5\u2009\u00b1\u20093.33 mmHg (95% confidence interval \u22122.55 to 1.47 mmHg). CFD predicted a reduction of the peak systolic pressure drop after treatment that ranged from 17.6\u2009\u00b1\u20095.56 mmHg to 6.7\u2009\u00b1\u20095.58 mmHg. The posttreatment bias was 3.0\u2009\u00b1\u20092.91 mmHg (95% CI \u22121.74 to 5.43 mmHg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peak systolic pressure drops can be reliably calculated using MRI\u2010based CFD in a clinical setting. Therefore, CFD might be an attractive noninvasive alternative to diagnostic catheterization. <jats:bold>J. Magn. Reson. Imaging 2015;41:909\u2013916<\/jats:bold>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24639","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T08:08:06Z","timestamp":1397203686000},"page":"909-916","source":"Crossref","is-referenced-by-count":98,"title":["MRI\u2010based computational fluid dynamics for diagnosis and treatment prediction: Clinical validation study in patients with coarctation of aorta"],"prefix":"10.1002","volume":"41","author":[{"given":"Leonid","family":"Goubergrits","sequence":"first","affiliation":[{"name":"Biofluid Mechanics Laboratory Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Germany"},{"name":"Non\u2010Invasive Cardiac Imaging in Congenital Heart Disease Unit Charit\u00e9\u2010Universit\u00e4tsmedizin, Berlin, and German Heart Institute Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenie","family":"Riesenkampff","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Paediatric Cardiology Deutsches Herzzentrum Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlo","family":"Yevtushenko","sequence":"additional","affiliation":[{"name":"Biofluid Mechanics Laboratory Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schaller","sequence":"additional","affiliation":[{"name":"Biofluid Mechanics Laboratory Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kertzscher","sequence":"additional","affiliation":[{"name":"Biofluid Mechanics Laboratory Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin 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