{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:15:46Z","timestamp":1790399746458,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":462,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Magn. Reson. Imaging"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1002\/jmri.24665","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T06:10:52Z","timestamp":1401171052000},"page":"1326-1331","source":"Crossref","is-referenced-by-count":106,"title":["Decreased \u03b3-aminobutyric acid levels in the parietal region of patients with Alzheimer's disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Xue","family":"Bai","sequence":"first","affiliation":[{"name":"Shandong Medical Imaging Research Institute, Shandong University; Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.E.","family":"Edden","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science; The Johns Hopkins University School of Medicine; Baltimore Maryland USA"},{"name":"F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute; Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Shandong Medical Imaging Research Institute, Shandong University; Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Medical Imaging Research Institute, Shandong University; Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lebin","family":"Wu","sequence":"additional","affiliation":[{"name":"Shandong Medical Imaging Research Institute, Shandong University; Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong Medical Imaging Research Institute, Shandong University; Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital, Shandong University; Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queenie","family":"Chan","sequence":"additional","affiliation":[{"name":"Philips Healthcare, 6\/F, Core Building 1, Hong Kong Science Park, Shatin; New Territories Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Philips Healthcare; Philips Innovation Campus Shanghai Building 1 No. 10 Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Barker","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science; The Johns Hopkins University School of Medicine; Baltimore Maryland USA"},{"name":"F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute; Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"10.1002\/jmri.24665-BIB0001|jmri24665-cit-0001","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/070674370404900705","article-title":"GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia","volume":"49","author":"Lanctot","year":"2004","journal-title":"Can J Psychiatry"},{"key":"10.1002\/jmri.24665-BIB0002|jmri24665-cit-0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2183\/pjab.89.139","article-title":"Synaptic inhibition and gamma-aminobutyric acid in the mammalian central nervous system","volume":"89","author":"Obata","year":"2013","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"10.1002\/jmri.24665-BIB0003|jmri24665-cit-0003","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s002100000346","article-title":"Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology","volume":"363","author":"Seidl","year":"2001","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1002\/jmri.24665-BIB0004|jmri24665-cit-0004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0006-3223(97)00300-4","article-title":"Cognitive functioning and GABAA\/benzodiazepine receptor binding in schizophrenia: a 123I-iomazenil SPET study","volume":"43","author":"Ball","year":"1998","journal-title":"Biol Psychiatry"},{"key":"10.1002\/jmri.24665-BIB0005|jmri24665-cit-0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0361-9230(97)00347-X","article-title":"GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited","volume":"45","author":"Marczynski","year":"1998","journal-title":"Brain Res Bull"},{"key":"10.1002\/jmri.24665-BIB0006|jmri24665-cit-0006","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.pnpbp.2007.12.011","article-title":"High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease","volume":"32","author":"Bartha","year":"2008","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1002\/jmri.24665-BIB0007|jmri24665-cit-0007","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J","article-title":"Simultaneous in vivo spectral editing and water suppression","volume":"11","author":"Mescher","year":"1998","journal-title":"NMR Biomed"},{"key":"10.1002\/jmri.24665-BIB0008|jmri24665-cit-0008","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroimage.2006.06.016","article-title":"In vivo detection of gray and white matter differences in GABA concentration in the human brain","volume":"33","author":"Choi","year":"2006","journal-title":"Neuroimage"},{"key":"10.1002\/jmri.24665-BIB0009|jmri24665-cit-0009","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1523\/JNEUROSCI.6158-09.2010","article-title":"GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression","volume":"30","author":"Yoon","year":"2010","journal-title":"J Neurosci"},{"key":"10.1002\/jmri.24665-BIB0010|jmri24665-cit-0010","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.57.4.626","article-title":"Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study","volume":"57","author":"Huang","year":"2001","journal-title":"Neurology"},{"key":"10.1002\/jmri.24665-BIB0011|jmri24665-cit-0011","first-page":"509","article-title":"[Developmental disorders in the fourth edition of the American classification: diagnostic and statistical manual of mental disorders (DSM IV - optional book)]","volume":"28","author":"Gmitrowicz","year":"1994","journal-title":"Psychiatr Pol"},{"key":"10.1002\/jmri.24665-BIB0012|jmri24665-cit-0012","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1002\/jmri.24665-BIB0013|jmri24665-cit-0013","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1002\/jmri.24665-BIB0014|jmri24665-cit-0014","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/mrm.1910380611","article-title":"Homocarnosine and the measurement of neuronal pH in patients with epilepsy","volume":"38","author":"Rothman","year":"1997","journal-title":"Magn Reson Med"},{"key":"10.1002\/jmri.24665-BIB0015|jmri24665-cit-0015","article-title":"Gannet: a batch-processing tool for the quantitative analysis of GABA-edited MRS spectra","author":"Edden","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"10.1002\/jmri.24665-BIB0016|jmri24665-cit-0016","article-title":"Frequency and phase drift correction of magnetic resonance spectroscopy data by spectral registration in the time domain","author":"Near","year":"2014","journal-title":"Magn Reson Med"},{"key":"10.1002\/jmri.24665-BIB0017|jmri24665-cit-0017","first-page":"687","article-title":"Magnetic resonance spectroscopy in Alzheimer's disease","volume":"9","author":"Graff-Radford","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1002\/jmri.24665-BIB0018|jmri24665-cit-0018","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1212\/WNL.56.5.592","article-title":"Magnetic resonance spectroscopy in AD","volume":"56","author":"Valenzuela","year":"2001","journal-title":"Neurology"},{"key":"10.1002\/jmri.24665-BIB0019|jmri24665-cit-0019","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1002\/jmri.24665-BIB0020|jmri24665-cit-0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1118\/1.597289","article-title":"Segmentation of MRS signals using ASPECT (analysis of SPectra using Eigenvector Decomposition of Targets)","volume":"21","author":"Roebuck","year":"1994","journal-title":"Med Phys"},{"key":"10.1002\/jmri.24665-BIB0021|jmri24665-cit-0021","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2045-3701-3-19","article-title":"Development and specification of GABAergic cortical interneurons","volume":"3","author":"Kelsom","year":"2013","journal-title":"Cell Biosci"},{"key":"10.1002\/jmri.24665-BIB0022|jmri24665-cit-0022","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/brain\/111.4.785","article-title":"Gamma-aminobutyric acid concentration in brain tissue at two stages of Alzheimer's disease","volume":"111","author":"Lowe","year":"1988","journal-title":"Brain"},{"key":"10.1002\/jmri.24665-BIB0023|jmri24665-cit-0023","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ana.410190307","article-title":"Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type","volume":"19","author":"Sasaki","year":"1986","journal-title":"Ann Neurol"},{"key":"10.1002\/jmri.24665-BIB0024|jmri24665-cit-0024","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/ana.410200510","article-title":"A postmortem study of amino acid neurotransmitters in Alzheimer's disease","volume":"20","author":"Ellison","year":"1986","journal-title":"Ann Neurol"},{"key":"10.1002\/jmri.24665-BIB0025|jmri24665-cit-0025","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/jnc.12003","article-title":"Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study","volume":"123","author":"Nilsen","year":"2012","journal-title":"J Neurochem"},{"key":"10.1002\/jmri.24665-BIB0026|jmri24665-cit-0026","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.3233\/JAD-2012-112072","article-title":"Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease","volume":"31","author":"Mlynarik","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.1002\/jmri.24665-BIB0027|jmri24665-cit-0027","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0074-7696(08)60771-8","article-title":"Enzymes involved in glutamatergic and GABAergic neurotransmission","volume":"147","author":"Kugler","year":"1993","journal-title":"Int Rev Cytol"},{"key":"10.1002\/jmri.24665-BIB0028|jmri24665-cit-0028","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/JAD-2011-110830","article-title":"Hippocampal GABAergic neurons are susceptible to amyloid-beta toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model","volume":"29","author":"Krantic","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.1002\/jmri.24665-BIB0029|jmri24665-cit-0029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jns.2012.08.013","article-title":"Regional differences in cortical benzodiazepine receptors of Alzheimer, vascular, and mixed dementia patients","volume":"323","author":"Hanyu","year":"2012","journal-title":"J Neurol Sci"},{"key":"10.1002\/jmri.24665-BIB0030|jmri24665-cit-0030","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s00259-010-1409-1","article-title":"SPECT imaging of GABA(A)\/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment","volume":"37","author":"Pappata","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1002\/jmri.24665-BIB0031|jmri24665-cit-0031","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1471-4159.2007.04832.x","article-title":"GABA(A) receptors in aging and Alzheimer's disease","volume":"103","author":"Rissman","year":"2007","journal-title":"J Neurochem"},{"key":"10.1002\/jmri.24665-BIB0032|jmri24665-cit-0032","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.neurobiolaging.2009.12.014","article-title":"Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease","volume":"32","author":"Luchetti","year":"2011","journal-title":"Neurobiol Aging"},{"key":"10.1002\/jmri.24665-BIB0033|jmri24665-cit-0033","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/mrm.24391","article-title":"Barker PB. Macromolecule-suppressed GABA-edited magnetic resonance spectroscopy at 3T","volume":"68","author":"Edden","year":"2012","journal-title":"Magn Reson Med"},{"key":"10.1002\/jmri.24665-BIB0034|jmri24665-cit-0034","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V","article-title":"Proton NMR chemical shifts and coupling constants for brain metabolites","volume":"13","author":"Govindaraju","year":"2000","journal-title":"NMR Biomed"},{"key":"10.1002\/jmri.24665-BIB0035|jmri24665-cit-0035","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.neurobiolaging.2013.02.002","article-title":"Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment","volume":"34","author":"Clerx","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1002\/jmri.24665-BIB0036|jmri24665-cit-0036","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1017\/S1041610212000506","article-title":"Medial temporal lobe atrophy relates to executive dysfunction in Alzheimer's disease","volume":"24","author":"Oosterman","year":"2012","journal-title":"Int Psychogeriatr"},{"key":"10.1002\/jmri.24665-BIB0037|jmri24665-cit-0037","first-page":"491","article-title":"Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment","volume":"72","author":"Visser","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.24665","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jmri.24665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T16:06:44Z","timestamp":1625328404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.24665"}},"subtitle":["In Vivo GABA Levels Measurement in AD"],"short-title":[],"issued":{"date-parts":[[2014,5,27]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"URL":"https:\/\/doi.org\/10.1002\/jmri.24665","relation":{},"ISSN":["1053-1807"],"issn-type":[{"value":"1053-1807","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5,27]]}}}