{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:14:24Z","timestamp":1783181664606,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate trans\u2010left atrioventricular valve (LAVV) blood flow and optimize left ventricular inflow quantification in healthy controls and patients after atrioventricular septal defect (AVSD) correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010five patients after AVSD correction and 25 controls underwent 4DFlow MRI. Using streamline visualization in four\u2010 and two\u2010chamber views, inflow direction at early and late filling was defined at the annulus level and at the peak inflow velocity (PIV) level. Trans\u2010LAVV flow volume and velocity were assessed from a static 2D\u2010multiplanar\u2010reformat (MPR), a 4D\u2010MPR tracking LAVV annulus and a 4D\u2010MPR tracking the PIV\u2010level, angulated perpendicular to the inflow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients, on average 9\u00b0 more laterally directed inflow was found at the PIV\u2010level compared to controls. In controls, 4DFlow velocity mapping with LAVV annulus tracking resulted in lower absolute error with aortic flow (3 (1\u20138) mL) than with static 2D\u2010MPR (7 (4\u201316) mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). In patients, 4D\u2010MPR tracking the PIV\u2010level, resulted in lower absolute error with aortic flow (2 (1\u20134) mL) than with 4D\u2010MPR LAVV annulus tracking (6 (2\u201310) mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Streamline visualization of 4DFlow MRI data revealed dynamic trans\u2010LAVV inflow and more lateral flow after AVSD correction. Streamline visualization improved trans\u2010LAVV flow quantification as the positioning and angulation of the measurement plane was optimized, allowing an accurate assessment of left ventricular inflow. <jats:bold>J. Magn. Reson. Imaging 2015;41:1512\u20131520.<\/jats:bold> \u00a9 <jats:bold>2014 Wiley Periodicals, Inc.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24735","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T11:54:18Z","timestamp":1408535658000},"page":"1512-1520","source":"Crossref","is-referenced-by-count":38,"title":["Characterization and improved quantification of left ventricular inflow using streamline visualization with 4DFlow MRI in healthy controls and patients after atrioventricular septal defect correction"],"prefix":"10.1002","volume":"41","author":[{"given":"Emmeline E.","family":"Calkoen","sequence":"first","affiliation":[{"name":"Division of Paediatric Cardiology, Department of Paediatrics Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Anatomy and Embryology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno A.W.","family":"Roest","sequence":"additional","affiliation":[{"name":"Division of Paediatric Cardiology, Department of Paediatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia J.M.","family":"Kroft","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.","family":"van der Geest","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique R.M.","family":"Jongbloed","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"van den Boogaard","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico A.","family":"Blom","sequence":"additional","affiliation":[{"name":"Division of Paediatric Cardiology, Department of Paediatrics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Hazekamp","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"de Roos","sequence":"additional","affiliation":[{"name":"Department of Radiology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J.M.","family":"Westenberg","sequence":"additional","affiliation":[{"name":"Department of 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