{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:42:00Z","timestamp":1778910120409,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T00:00:00Z","timestamp":1409356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate cystic fibrosis (CF) subjects over 4 years using <jats:sup>3<\/jats:sup>He magnetic resonance imaging (MRI), pulmonary function tests, and track hospitalization and physician visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Five CF adults provided written informed consent to an approved protocol and underwent MRI, spirometry, and plethysmography at baseline, 7 days, and 4\u2009\u00b1\u20091 years later. <jats:sup>3<\/jats:sup>He MRI ventilation defect percent (VDP) was generated for all subjects and timepoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 4 years, mean forced expiratory volume in 1 second \/ forced vital capacity (FEV<jats:sub>1<\/jats:sub>\/FVC) was lower (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) in all subjects and there were no other pulmonary function test changes. Two CF adults showed significantly elevated (worse) <jats:sup>3<\/jats:sup>He VDP at baseline and after 4 years they had significantly greater (worsened) VDP (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), without a significant FEV<jats:sub>1<\/jats:sub> decline (<jats:italic>P<\/jats:italic>\u2009=\u20090.06) but with a greater number of exacerbations (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Baseline VDP strongly correlated with FEV<jats:sub>1<\/jats:sub> (r<jats:sup>2<\/jats:sup>\u2009=\u20090.98, <jats:italic>P<\/jats:italic>\u2009=\u20090.0007) at 4\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For two CF subjects, VDP was significantly worse at baseline and worsened over 4 years, which was in agreement with a greater number of hospitalizations and clinic visits. These results are limited by the very small sample size, but the strong VDP correlation with longitudinal changes in FEV<jats:sub>1<\/jats:sub> generates the hypothesis that abnormal VDP may temporally precede FEV<jats:sub>1<\/jats:sub> decline in CF subjects; this must be tested in a larger CF study. <jats:bold>J. Magn. Reson. Imaging 2015;41:1701\u20131707<\/jats:bold>. \u00a9 <jats:bold>2014 Wiley Periodicals, Inc<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24744","type":"journal-article","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T09:15:10Z","timestamp":1409390110000},"page":"1701-1707","source":"Crossref","is-referenced-by-count":20,"title":["Differences in hyperpolarized <sup>3<\/sup>He ventilation imaging after 4 years in adults with cystic fibrosis"],"prefix":"10.1002","volume":"41","author":[{"given":"Gregory A.","family":"Paulin","sequence":"first","affiliation":[{"name":"Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario London Canada"},{"name":"Department of Medical Biophysics University of Western Ontario London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Svenningsen","sequence":"additional","affiliation":[{"name":"Imaging Research Laboratories, Robarts Research Institute, University 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