{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:07:33Z","timestamp":1780718853061,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171745"],"award-info":[{"award-number":["81171745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Orthopedic Clinical Medical Center of Nanjing City"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the progression of cartilage degeneration using delayed gadolinium\u2010enhanced MRI of cartilage (dGEMRIC) and T2 mapping in a mini\u2010pig model of osteoarthritis (OA) caused by anterior cruciate ligament transection (ACLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve mini\u2010pigs underwent ACLT in the left knee and were monitored by dGEMRIC (T1, gadolinium [Gd]) and T2 mapping after 2, 4, or 6 weeks (n\u2009=\u20094 each). No ACLT surgery was performed in four healthy control mini\u2010pigs, which were also monitored by dGEMRIC and T2 mapping. Cartilage samples from the weight\u2010bearing regions of the left medial femoral condyles were collected for macroscopic, histological, immunohistochemical, and biochemical analysis. Correlations between biochemical contents and T1,Gd and T2 values were evaluated using Pearson correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T1,Gd values were gradually reduced and T2 values increased over time. Cartilage surfaces showed roughness at 4 weeks and additional defects at 6 weeks. Glycosaminoglycan (GAG) distribution and content gradually reduced over time (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and collagen distribution and anisotropy were obviously changed at 6 weeks. However, collagen content did not differ significantly among postoperative timepoints. GAG content was positively related to T1,Gd values (<jats:italic>r<\/jats:italic>\u2009=\u20090.888; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and negatively related to T2 values (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.865; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Collagen content had no discernible correlation with T1,Gd or T2 values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>dGEMRIC and T2 mapping can monitor the progression of cartilage degeneration in a mini\u2010pig model of ACLT\u2010induced OA, permitting early detection of OA. J. Magn. Reson. Imaging 2015;42:1032\u20131038.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24862","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T07:17:12Z","timestamp":1423207032000},"page":"1032-1038","source":"Crossref","is-referenced-by-count":11,"title":["Use of quantitative MRI for the detection of progressive cartilage degeneration in a mini\u2010pig model of osteoarthritis caused by anterior cruciate ligament transection"],"prefix":"10.1002","volume":"42","author":[{"given":"Bo","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Radiology the First Affiliated Hospital Nanjing Medical University Nanjing 210006 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyong","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqiang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"},{"name":"Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1705-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proghi.2006.02.003"},{"key":"e_1_2_6_5_1","first-page":"338","article-title":"Arthroscopic anterior cruciate ligament transection induces canine osteoarthritis","volume":"23","author":"Marshall KW","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20027"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.12.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0390"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1998.19310023.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.09.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20998"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.01.071"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22811"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300368h"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10389"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002772"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100120402"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0520"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01466630"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.03.017"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2616-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0822"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.311105084"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.06.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.07.012"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.03.069"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22249"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2009.0452"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.24862","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.24862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:25:12Z","timestamp":1696508712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.24862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/jmri.24862"],"URL":"https:\/\/doi.org\/10.1002\/jmri.24862","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}