{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:38:58Z","timestamp":1784590738600,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Foundation Fundaci\u00f3n Alfonso Mart\u00edn Escudero"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To differentiate pathologic from benign vertebral fractures, which can be challenging. We hypothesized that dynamic contrast\u2010enhanced magnetic resonance imaging (DCE\u2010MRI) can aid in the noninvasive distinction between pathologic and benign fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Consecutive patients with vertebral fractures who underwent DCE\u2010MRI, biopsy, and kyphoplasty were reviewed. Forty\u2010seven fractures were separated into pathologic and benign fractures. Benign fractures were in turn separated into acute and chronic fractures for further comparison. Regions of interest (ROIs) were placed over fractured vertebral bodies. Perfusion parameters: plasma volume (V<jats:sub>p<\/jats:sub>), K<jats:sup>trans<\/jats:sup>, wash\u2010in slope, peak enhancement, and area under the curve (AUC) were measured and compared between the three different groups of fractures. A Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test was conducted to assess the difference between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pathologic fractures had significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.01) perfusion parameters (V<jats:sub>p<\/jats:sub>, K<jats:sup>trans<\/jats:sup>, wash\u2010in slope, peak enhancement, and AUC) compared with benign fractures. We also found significant differences (<jats:italic>P<\/jats:italic> &lt; 0.001) in all parameters between chronic and acute fractures. V<jats:sub>p<\/jats:sub> and K<jats:sup>trans<\/jats:sup> were able to differentiate between pathologic and acute fractures (<jats:italic>P<\/jats:italic> &lt; 0.01). No significant differences were found with peak enhancement (<jats:italic>P<\/jats:italic>\u2009=\u20090.21) and AUC (<jats:italic>P<\/jats:italic>\u2009=\u20090.4) between pathologic and acute fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrate that <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted DCE\u2010MRI has potential to differentiate between pathologic vs. benign, acute vs. chronic, and most important, benign acute vs. pathologic vertebral fractures. J. Magn. Reson. Imaging 2015;42:1039\u20131047.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24863","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T07:13:54Z","timestamp":1423120434000},"page":"1039-1047","source":"Crossref","is-referenced-by-count":35,"title":["Differentiating benign from malignant vertebral fractures using <i>T<\/i><sub>1<\/sub>\u2010weighted dynamic contrast\u2010enhanced MRI"],"prefix":"10.1002","volume":"42","author":[{"given":"Julio","family":"Arevalo\u2010Perez","sequence":"first","affiliation":[{"name":"Department of Radiology Memorial Sloan\u2010Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung K.","family":"Peck","sequence":"additional","affiliation":[{"name":"Department of Radiology Memorial Sloan\u2010Kettering Cancer Center New York New York USA"},{"name":"Department of Medical Physics Memorial Sloan\u2010Kettering Cancer Center New York New York 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