{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:29:40Z","timestamp":1792301380797,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the asymmetry of quantitative cerebral blood flow (CBF) values in interictal temporal lobe epilepsy (TLE) patients with (TLE\u2010MTS) and without (TLE\u2010no) mesial temporal sclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six TLE patients (14 TLE\u2010MTS\/12 TLE\u2010no) and 22 controls were studied with a three\u2010dimensional whole\u2010brain pseudocontinuous arterial spin\u2010labeling technique at 3.0 Tesla. Regions of interest were placed at the bilateral hippocampal heads, amygdalas and temporal lobes to get the average regional cerebral blood flow (rCBF) and calculate asymmetry indices (AIs). Statistical parametric mapping detected the whole\u2010brain CBF changes of the two subgroups (right\u2010sided).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AIs of the hippocampus and amygdala in TLE\u2010MTS and AIs of hippocampus in TLE\u2010no were significantly different versus controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>P<\/jats:italic>\u2009=\u20090.001, and <jats:italic>P<\/jats:italic>\u2009=\u20090.013). The lateralizing sensitivity increased to 96.154% by combining structural MRI and AIs of rCBF with optimal cutoff values. Hypoperfusion regions in the right TLE\u2010MTS mainly clustered in the bilateral temporal lobes, frontal lobes, insular lobes, and left caudate nucleus. The right TLE\u2010no showed hypoperfusion in the bilateral temporal lobes, frontal lobes, right insular lobe, parietal lobe, occipital lobe, and caudate nucleus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asymmetry of CBF in the TLE\u2010MTS and TLE\u2010no is different and improves MRI performance in lateralizing the TLE. J. Magn. Reson. Imaging 2015;42:1386\u20131397.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24920","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T12:39:16Z","timestamp":1429274356000},"page":"1386-1397","source":"Crossref","is-referenced-by-count":42,"title":["Asymmetry of cerebral blood flow measured with three\u2010dimensional pseudocontinuous arterial spin\u2010labeling mr imaging in temporal lobe epilepsy with and without mesial temporal sclerosis"],"prefix":"10.1002","volume":"42","author":[{"given":"Xiaoqin","family":"Guo","sequence":"first","affiliation":[{"name":"Shandong Medical Imaging Research Institute Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangchen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shandong Provincial Hospital  Jinan People's Republic of 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