{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:44Z","timestamp":1786978184163,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the interexamination repeatability and spatial heterogeneity of liver iron and fat measurements using a magnetic resonance imaging (MRI)\u2010based multistep adaptive fitting algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This prospective observational study was Institutional Review Board\u2010approved and Health Insurance Portability and Accountability Act\u2010compliant. Written informed consent was waived. In all, 150 subjects were imaged on 3T MRI systems. A whole\u2010liver volume acquisition was performed twice using a six\u2010echo 3D spoiled gradient echo sequence during two immediately adjacent examinations. Colocalized regions of interest (ROIs) in three different hepatic segments were placed for R\n                      <jats:sub>2<\/jats:sub>\n                      * and proton density fat fraction (PDFF) measurements by two readers independently. Mean R\n                      <jats:sub>2<\/jats:sub>\n                      * and PDFF values between readers and acquisitions were compared using the Wilcoxon signed\u2010rank test, intraclass correlation coefficients (ICCs), linear regression, Bland\u2013Altman analysis, and analysis of variance (ANOVA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean R\n                      <jats:sub>2<\/jats:sub>\n                      * and PDFF values across all ROIs and measurements were 51.2\u2009\u00b1\u200925.2 s\n                      <jats:sup>\u22121<\/jats:sup>\n                      and 6.9\u2009\u00b1\u20096.4%, respectively. Mean R\n                      <jats:sub>2<\/jats:sub>\n                      * and PDFF values showed no significant differences between the two acquisitions (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05\u20130.87). Between the two acquisitions, R\n                      <jats:sub>2<\/jats:sub>\n                      * and PDFF values demonstrated almost perfect agreement (ICCs\u2009=\u20090.979\u20130.994) and excellent correlation (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.958\u20130.989). Bland\u2013Altman analysis also demonstrated excellent agreement. In the ANOVA, the individual patient and ROI location were significant effects for both R\n                      <jats:sub>2<\/jats:sub>\n                      * and PDFF values (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      MRI\u2010based R\n                      <jats:sub>2<\/jats:sub>\n                      * and PDFF measurements are repeatable between examinations. Between\u2010measurement changes in R\n                      <jats:sub>2<\/jats:sub>\n                      * of more than 10.1 s\n                      <jats:sup>\u22121<\/jats:sup>\n                      and in PDFF of more than 1.7% are likely due to actual tissue changes. Liver iron and fat content are variable between hepatic segments. J. Magn. Reson. Imaging 2015;42:1281\u20131290.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.24922","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T06:04:51Z","timestamp":1430114691000},"page":"1281-1290","source":"Crossref","is-referenced-by-count":47,"title":["Interexamination repeatability and spatial heterogeneity of liver iron and fat quantification using MRI\u2010based multistep adaptive fitting algorithm"],"prefix":"10.1002","volume":"42","author":[{"given":"Keitaro","family":"Sofue","sequence":"first","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"},{"name":"Department of Radiology Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Mileto","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina 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