{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T16:38:54Z","timestamp":1783787934592,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To elucidate the association between growth plate injury size and the beginning of physeal growth disturbance by MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two 5\u2010week\u2010old male Japanese white rabbits were used. Injuries were made to the right tibial proximal growth plate central region with a 3.0\u2010mm and a 1.2\u2010mm drill. The left tibia was used as a control. MRI (7.04 Tesla [T], gradient echo: repetition time [TR], 71.68 ms; echo time [TE], 3.60 ms; proton\u2010density weighted imaging: TR, 2000 ms; TE, 12 ms) of the growth plates was performed at 1, 4, 8, 10, and 12 weeks postinjury. Tibia length, histology, radiography, and microcomputed tomography (\u00b5CT) were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MRI showed that at 10 and 12 weeks postinjury in the 3.0\u2010mm group, the medial and lateral growth plates in the noninjured regions were significantly reduced compared with the controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). At 12 weeks postinjury in the 1.2\u2010mm group, medial and lateral growth plates in the noninjured regions were significantly reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Tibia length and histological growth plate height of injured side in both groups were significantly shorter than controls at 12 weeks postinjury (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Comparison with the controls showed no significant difference at any of the time periods in either the 3.0\u2010 or 1.2\u2010mm group according to the radiographic studies (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Bony bridges developed in all the subjects of the 3.0\u2010mm group and in five of eight subjects of the 1.2\u2010mm group, as shown by \u00b5CT images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggested that growth plate injury size was associated with the timing of the beginning of physeal growth disturbance. J. MAGN. RESON. 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