{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:11:23Z","timestamp":1791976283646,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"crossref","award":["CMRPG-370444"],"award-info":[{"award-number":["CMRPG-370444"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"crossref","award":["290262"],"award-info":[{"award-number":["290262"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC100-2325-B-182-008"],"award-info":[{"award-number":["NSC100-2325-B-182-008"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC 103-2314-B-182A-006"],"award-info":[{"award-number":["NSC 103-2314-B-182A-006"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NMRPD1A0842. IRB 97-2366B."],"award-info":[{"award-number":["NMRPD1A0842. IRB 97-2366B."]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the diagnostic accuracy of contrast\u2010enhanced (CE) magnetic resonance imaging (MRI) and diffusion\u2010weighted MRI (DWI) in the differentiation between uterine leiomyosarcoma (LMS) \/ smooth muscle tumor with uncertain malignant potential (STUMP) and benign leiomyoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A consecutive cohort of 8 LMS\/STUMP and 25 benign leiomyomas underwent pelvic MRI exam at 3T. Two radiologists independently evaluated images based on CE\u2010MRI (central nonenhancement at equilibrial phase) and DWI (hyperintensity on b = 1000 s\/mm<jats:sup>2<\/jats:sup> and hypointensity on apparent diffusion coefficients [ADC] map). The ADC values were calculated from b = 0 and 1000 s\/mm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CE\u2010MRI yielded a significantly superior diagnostic accuracy (0.94 vs. 0.52) and a significantly higher specificity (0.96 vs. 0.36) than DWI (<jats:italic>P<\/jats:italic> &lt; 0.05 for both), and remained a comparably high sensitivity as DWI (0.88 vs. 1.00). A combination of DWI and ADC value &lt;1.08 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s (determined by receiver operating characteristic analysis) improved diagnostic accuracy, sensitivity, and specificity of DWI to 0.88, 0.88, and 0.88, respectively, by post\u2010hoc analysis based on the same study cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For prospective differentiation between uterine LMS\/STUMP and benign leiomyoma, CE\u2010MRI can provide accurate information and is preferable to DWI. Combination of DWI and ADC values can achieve a comparable diagnostic accuracy to CE\u2010MRI. J. Magn. Reson. Imaging 2016;43:333\u2013342.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.24998","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T15:28:09Z","timestamp":1442590089000},"page":"333-342","source":"Crossref","is-referenced-by-count":129,"title":["Comparison of the diagnostic accuracy of contrast\u2010enhanced MRI and diffusion\u2010weighted MRI in the differentiation between uterine leiomyosarcoma \/ smooth muscle tumor with uncertain malignant potential and benign leiomyoma"],"prefix":"10.1002","volume":"43","author":[{"given":"Gigin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Institute for Radiological Research Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical Trial Center Chang Gung Memorial Hospital and Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Institute for Radiological Research Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon\u2010Kwan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Institute for Radiological Research Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Hang","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Institute for Radiological Research Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shir\u2010Hwa","family":"Ueng","sequence":"additional","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital and Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gynecology Oncology Research Center Chang Gung Memorial Hospital and Chang Gung University, Linkou Medical Center Guishan Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Chen","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation Chang Gung Memorial Hospital and Chang Gung University, Linkou Medical Center Guishan Taoyuan 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