{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:52:55Z","timestamp":1791075175432,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine whether magnetic resonance enterography (MRE) performed without intravenous contrast injection is diagnostically noninferior to conventional contrast\u2010enhanced MRE (CE\u2010MRE) in patients with Crohn's disease (CD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was an Institutional Review Board (IRB)\u2010approved retrospective study. Ninety\u2010six patients (52 male and 44 female; 47.18 years \u00b1 13.6) with a diagnosis of CD underwent MRE at 1.5T including <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted single\u2010shot turbo\u2010spin\u2010echo, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted spectral fat presaturation with inversion recovery (SPAIR), <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted balanced fast\u2010field\u2010echo MR sequences, and CE\u2010MRE consisting in <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted breath\u2010hold THRIVE 3D MRI sequences after administration of gadobenate dimeglumine (0.2 mL\/kg of body weight). Unenhanced MRE, CE\u2010MRE, and unenhanced MRE plus CE\u2010MRE were reviewed in separate sessions with blinding by two readers in consensus, and subsequently by two other readers independently considering a subgroup of 20 patients. Crohn's Disease Endoscopic Index of Severity (CDEIS) and\/or histologic analysis of the surgical specimen were considered as reference standards for the assessment of inflammatory activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients revealed prevalently active (<jats:italic>n<\/jats:italic> = 55 patients) or quiescent CD (<jats:italic>n<\/jats:italic> = 41 patients). The agreement between unenhanced MRE vs. CE\u2010MRE in interpreting active bowel inflammation was 96% (123\/128 bowel segments; one\u2010sided 95% confidence interval [CI], &gt;94.4%). Unenhanced MRE vs. CE\u2010MRE vs. unenhanced MRE plus CE\u2010MRE revealed a diagnostic accuracy of 93% [90\/96] vs. 92% [88\/96] vs. 97% [93\/96] (<jats:italic>P<\/jats:italic> &gt; 0.05) in the diagnosis of active CD. Interreader agreement was very good for all variables (\u03ba value = 0.8\u20130.9) except for the measurement of the length of disease (\u03ba value = 0.45).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unenhanced MRE was noninferior to CE\u2010MRE in diagnosing active inflammation in patients with CD. J. MAGN. RESON. 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