{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:07:13Z","timestamp":1790460433435,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["1R01DK087877"],"award-info":[{"award-number":["1R01DK087877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["EB001981"],"award-info":[{"award-number":["EB001981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"General Electric Healthcare grant"},{"DOI":"10.13039\/501100008980","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Radiologie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008980","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess interplatform reproducibility of liver stiffness (LS) and spleen stiffness (SS) measured with magnetic resonance elastography (MRE) based on a 2D gradient echo (GRE) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective Health Insurance Portability and Accountability Act (HIPAA)\u2010compliant and Institutional Review Board (IRB)\u2010approved study involved 12 subjects (five healthy volunteers and seven patients with liver disease). A multislice 2D\u2010GRE\u2010based MRE sequence was performed using two systems from different vendors (3.0T GE and 1.5T Siemens) on the same day. Two independent observers measured LS and SS on confidence maps. Bland\u2013Altman analysis (with coefficient of reproducibility, CR), coefficient of variability (CV), and intraclass correlation (ICC) were used to analyze interplatform, intra\u2010 and interobserver variability. Human data were validated using a gelatin\u2010based phantom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was excellent reproducibility of phantom stiffness measurement (CV 4.4%). Mean LS values were 3.44\u20133.48 kPa and 3.62\u20133.63 kPa, and mean SS values were 7.54\u20137.91 kPa and 8.40\u20138.85 kPa at 3.0T and 1.5T for observers 1 and 2, respectively. The mean CVs between platforms were 9.2%\u201311.5% and 13.1%\u201314.4% for LS and SS, respectively, for observers 1 and 2. There was excellent interplatform reproducibility (ICC &gt;0.88 and CR &lt;36.2%) for both LS and SS, and excellent intra\u2010 and interobserver reproducibility (intraobserver: ICC &gt;0.99, CV &lt;2.1%, CR &lt;6.6%; interobserver: ICC &gt;0.97, CV and CR &lt;16%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that 2D\u2010GRE MRE provides platform\u2010 and observer\u2010independent LS and SS measurements. J. Magn. Reson. Imaging 2016;43:1064\u20131072.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25077","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T16:19:24Z","timestamp":1444925964000},"page":"1064-1072","source":"Crossref","is-referenced-by-count":69,"title":["Interplatform reproducibility of liver and spleen stiffness measured with MR elastography"],"prefix":"10.1002","volume":"43","author":[{"given":"Temel Kaya","family":"Yasar","sequence":"first","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Wagner","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavia","family":"Bane","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Besa","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Babb","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kannengiesser","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions, MR Applications Development Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Fung","sequence":"additional","affiliation":[{"name":"GE Healthcare, MR Applications &amp; Workflow New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Ehman","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Taouli","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai New York New York USA"},{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2014.10.003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0322"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523081928"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2014.05.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2452061673"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132592"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2978-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.001"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.049"},{"key":"e_1_2_5_13_1","first-page":"1394","article-title":"Assessment of portal hypertension and high\u2010risk oesophageal varices with liver and spleen three\u2010dimensional multifrequency MR elastography in liver cirrhosis","volume":"24","author":"Ronot M","year":"2014","journal-title":"Eur Radiol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24049"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24505"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14141210"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20449"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22066"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22716"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23958"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0282-y"},{"key":"e_1_2_5_22_1","unstructured":"RoystonT YasarT MaginR.Geometric focusing of high frequency shear waves for noninvasive high resolution MR elastography. 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