{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:40:43Z","timestamp":1696408843854},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council","award":["G0802470"],"award-info":[{"award-number":["G0802470"]}]},{"name":"CRUK Cancer Imaging Centre in association with the Medical Research Council and Department of Health (England)","award":["C1060\/A10334"],"award-info":[{"award-number":["C1060\/A10334"]}]},{"name":"NHS funding to the NIHR Clinical Research Facility in Imaging and the NIHR Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the clinical utility of the reverse gradient algorithm in correcting distortions in diffusion\u2010weighted images of the cervix and for increasing diagnostic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010one patients ages 25\u201372 years (mean 40 \u00b1 11 years) with suspected or early stage cervical cancer were imaged at 3T using an endovaginal coil. <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted (W) and diffusion\u2010weighted images with right and left phase\u2010encode gradient directions were obtained coronal to the cervix (b = 0, 100, 300, 500, 800  s mm<jats:sup>\u22122<\/jats:sup>). Differences in angle of the endocervical canal to the x\u2010axis between <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>W and right\u2010gradient, left\u2010gradient, and corrected images were measured. Uncorrected and corrected images were assessed for diagnostic performance when viewed together with <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>W images by two independent observers against subsequent histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The angles of the endocervical canal relative to the x\u2010axis were significantly different between the <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>W images and the right\u2010gradient images (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), approached significance for left\u2010gradient images (<jats:italic>P<\/jats:italic>\u2009=\u20090.055), and were not significantly different after correction (<jats:italic>P<\/jats:italic>\u2009=\u20090.95). Corrected images enabled a definitive diagnosis in 34% (<jats:italic>n<\/jats:italic>\u2009=\u200914) of patients classified as equivocal on uncorrected images. Tumor volume in this subset was 0.18 \u00b1 0.44 cm<jats:sup>3<\/jats:sup> (mean \u00b1 SD; sensitivity of detection 100% [8\/8], specificity 50% [3\/6] for an experienced observer). Correction did not improve diagnostic performance for the less\u2010experienced observer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Distortion\u2010corrected diffusion\u2010weighted images improved correspondence with <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>W images and diagnostic performance in a third of cases. J. Magn. Reson. Imaging 2016;43:1218\u20131223.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25080","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T09:43:26Z","timestamp":1445334206000},"page":"1218-1223","source":"Crossref","is-referenced-by-count":5,"title":["Distortion correction of echo\u2010planar diffusion\u2010weighted images of uterine cervix"],"prefix":"10.1002","volume":"43","author":[{"given":"Nandita M.","family":"deSouza","sequence":"first","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Orton","sequence":"additional","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Downey","sequence":"additional","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Collins","sequence":"additional","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Giles","sequence":"additional","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey S.","family":"Payne","sequence":"additional","affiliation":[{"name":"CRUK\/EPSRC Cancer Imaging Centre Institute of Cancer Research and Royal Marsden NHS Foundation Trust Sutton Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"CRUK \u201cStats Team (June 2011) CancerStats Key Facts Cervical Cancer Technical Report Cancer Research UK \u201d2011 Cervical cancer statistics \u2014 Key Facts[cited 2015 July]; Available from:http:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/cervical-cancer."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10149.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2491072165"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340111"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390518"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.158935"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1298"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10690"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360620"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","unstructured":"JafarM GilesS MorganV SchmidtM LeachMO deSouzaNM. 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