{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:08:31Z","timestamp":1772482111283,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Doctor ZhouLizhi in the Department of Biomedical Statistical of Southern Medical University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the value of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation times in the rotating frame (<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1 or <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>rho) for evaluating liver fibrosis stage, compared to apparent diffusion coefficients (ADCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Liver fibrosis in model rats (<jats:italic>n<\/jats:italic>\u2009=\u200950) was produced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) injection. Five rats died during the experiment. Surviving model rats (<jats:italic>n<\/jats:italic>\u2009=\u200945) and controls (<jats:italic>n<\/jats:italic>\u2009=\u200915) were subjected to 3.0T MRI and the ADCs (b\u2010values: 0, 800\u2009s\/mm<jats:sup>2<\/jats:sup>) and <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1 values were determined. Liver fibrosis stage (F0\u2013F4) was defined based on METAVIR scoring. Nonparametric statistical methods and receiver operating characteristic (ROC) curve analyses were employed to determine diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean ADC and <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1 associated negatively (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.732 <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and positively (<jats:italic>r<\/jats:italic>\u2009=\u20090.863 <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), respectively, with severity of fibrosis stage. Analysis of ROC curves for fibrosis staging showed that the area under the curve (AUC) for <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1 (stage F0 vs. F1\u2013F4\u2009=\u20090.976, stage F0\u2013F1 vs. F2\u2013F4\u2009=\u20090.920, stage F0\u2013F2 vs. F3\u2013F4\u2009=\u20090.938, and stage F0\u2013F3 vs. F4\u2009=\u20090.931) was larger than that for ADCs (0.917, 0.924, 0.842, and 0.781, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ADC and <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1 values correlate with liver fibrosis stage. The performance of the <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1 parameter was superior to that of the ADC parameter in the differentiation of liver fibrosis stages in a CCl<jats:sub>4<\/jats:sub> rat model. J. Magn. Reson. Imaging 2016;43:1082\u20131089.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25084","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T08:28:50Z","timestamp":1445848130000},"page":"1082-1089","source":"Crossref","is-referenced-by-count":26,"title":["Assessment of liver fibrosis in rats by MRI with apparent diffusion coefficient and <i>T<\/i><sub>1<\/sub> relaxation time in the rotating frame"],"prefix":"10.1002","volume":"43","author":[{"given":"Genwen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Medical Image Center Shenzhen Bao'an Maternal and Child Health Hospital Shenzhen Guangdong Province China"},{"name":"Department of Medical Image Center Zhujiang Hospital, Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Image Center Zhujiang Hospital, Southern 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