{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:58:41Z","timestamp":1780444721298,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine whether intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) could detect parotid gland abnormalities in Sj\u00f6gren's syndrome (SS) patients who were not identified by conventional MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Ten consecutive patients with clinically proven SS who were not identified by conventional MRI were assessed by IVIM MRI with a 3.0T MRI scanner. Quantitative parameters (tissue diffusivity, D; pseudodiffusion coefficient, D*; perfusion fraction, f) derived from IVIM MRI were compared between the SS group and healthy control group (<jats:italic>n<\/jats:italic>\u2009=\u200915). A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of each significant parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excellent inter\u2010 and intrareader agreements were obtained during the measurement of D, f, and D* values (interreader, 0.980, 0.942, and 0.883; intrareader, 0.991, 0.952, and 0.896, respectively). All three parameters of the SS group were significantly higher than those of the healthy group (D, 1.049\u2009\u00b1\u20090.056 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s vs. 0.976\u2009\u00b1\u20090.116 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic>\u2009=\u20090.012; D*, 20.410\u2009\u00b1\u20091.786 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s vs. 18.764\u2009\u00b1\u20092.433 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic>\u2009=\u20090.013; f, 0.207\u2009\u00b1\u20090.003 vs. 0.182\u2009\u00b1\u20090.002, <jats:italic>P<\/jats:italic>\u2009=\u20090.004). ROC analysis showed that the f value had the best diagnostic performance (AUC, 0.712; Sensitivity, 0.80; Specificity, 0.57; Cutoff value, 0.185) in detecting the parotid gland abnormalities in early SS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IVIM MRI detected parotid gland abnormalities in early\u2010stage SS patients. J. Magn. Reson. Imaging 2016;43:1455\u20131461.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25096","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T16:09:14Z","timestamp":1447949354000},"page":"1455-1461","source":"Crossref","is-referenced-by-count":12,"title":["Feasibility study of using intravoxel incoherent motion mri to detect parotid gland abnormalities in early\u2010stage Sj\u00f6gren syndrome patients"],"prefix":"10.1002","volume":"43","author":[{"given":"Guo\u2010Yi","family":"Su","sequence":"first","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Quan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Nanjing Medical University Nanjing 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