{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:31:42Z","timestamp":1780410702495,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81501549"],"award-info":[{"award-number":["81501549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81571649"],"award-info":[{"award-number":["81571649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81571634"],"award-info":[{"award-number":["81571634"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["61172167"],"award-info":[{"award-number":["61172167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81227901"],"award-info":[{"award-number":["81227901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["61231004"],"award-info":[{"award-number":["61231004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171314"],"award-info":[{"award-number":["81171314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China (973 Program)","doi-asserted-by":"crossref","award":["2011CB707700"],"award-info":[{"award-number":["2011CB707700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National High Technology Research and Development Program of China (863 Program)","award":["2012AA021105"],"award-info":[{"award-number":["2012AA021105"]}]},{"name":"NSFC-NIH Biomedical collaborative research program","award":["81261120414"],"award-info":[{"award-number":["81261120414"]}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","award":["4132080"],"award-info":[{"award-number":["4132080"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"crossref","award":["7132108"],"award-info":[{"award-number":["7132108"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["K13JB00170"],"award-info":[{"award-number":["K13JB00170"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Research Funds for the Capital Health Development","award":["2011-2018-01"],"award-info":[{"award-number":["2011-2018-01"]}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"crossref","award":["ZYLX201511"],"award-info":[{"award-number":["ZYLX201511"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of Heilongjiang Educational Committee","award":["12531119"],"award-info":[{"award-number":["12531119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate both the gray matter (GM) and whiter matter (WM) alterations in a homogeneous cohort of early HIV\u2010infected patients by combining voxel\u2010based morphometry (VBM) and tract\u2010based spatial statistics (TBSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010six HIV and 26 control subjects enrolled in this study with 3D <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> and diffusion\u2010tensor imaging acquired on a 3.0T Siemens scanner. Group differences in regional GM were assessed using VBM analysis, while differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and relative anisotropy (RD) of WM were evaluated using TBSS analysis. After that, interactions between GM changes and white matter alterations were investigated by using a correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HIV\u2010infected patients displayed decreased GM volume, mainly located in the bilateral frontal cortices, bilateral anterior cingulate cortex, and left supplementary motor area (<jats:italic>P<\/jats:italic> &lt; 0.05, false discovery rate\u2010corrected). Meanwhile, the patient group showed decreased FA in the genu of capsule callosum, body of capsule callosum, and bilateral anterior corona radiate (<jats:italic>P<\/jats:italic> &lt; 0.05, family wise error [FEW]\u2010corrected). Areas of increased MD, RD, and AD in HIV patients were more extensive and observed in most skeleton locations (<jats:italic>P<\/jats:italic> &lt; 0.05, FEW\u2010corrected). The interaction analysis in the patient group revealed that there were no significant correlations between GM changes and WM alterations (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that structural brain alterations occurred early in HIV\u2010infected patients. The current study may shed further light on the potential brain effects of HIV. J. Magn. Reson. Imaging 2016;43:1474\u20131483.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25100","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T13:25:55Z","timestamp":1451481955000},"page":"1474-1483","source":"Crossref","is-referenced-by-count":38,"title":["Gray and white matter alterations in early HIV\u2010infected patients: Combined voxel\u2010based morphometry and tract\u2010based spatial statistics"],"prefix":"10.1002","volume":"43","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"School of Automation, Harbin University of Science and Technology Harbin China"},{"name":"Key Laboratory of Molecular Imaging, Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Imaging, Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Radiology Department You'an Hospital of Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchao","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Mechanical, Electrical &amp; Information Engineering, Shandong University Weihai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Radiology Department You'an Hospital of Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Imaging, Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106073442306"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318278b5b4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200001070-00008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00019.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-011-0032-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.1.97"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1527"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1372346"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0029-0"},{"key":"e_1_2_6_11_1","first-page":"2275","article-title":"Diffusion\u2010tensor MR imaging of the brain in human immunodeficiency virus\u2010positive patients","volume":"26","author":"Thurnher MM","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2489"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24129"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(00)00082-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.03.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-008-9120-8"},{"key":"e_1_2_6_17_1","first-page":"195","article-title":"Whole brain diffusion tensor imaging in HIV\u2010associated cognitive impairment","volume":"25","author":"Ragin AB","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318159d807"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.030"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0135-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5883-y"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2013.10.012"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0290"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2452060445"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.796284"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-044451741-8\/50003-2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14842-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502548102"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21594"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2010.01.002"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.08.030"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-05-03284.1995"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-23"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3647-07.2007"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:56:20Z","timestamp":1696611380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/jmri.25100"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25100","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]}}}