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Four compressed\u2010sensing methods were developed: A) VDPoisson scan reconstructed using spatial wavelets; B) added temporal total variation to A; C) VDRad scan using the same reconstruction as in B; and D) added motion compensation to C. With Institutional Review Board (IRB) approval and Health Insurance Portability and Accountability Act (HIPAA) compliance, 23 consecutive patients (eight females, mean 6.3 years) referred for ferumoxytol\u2010enhanced CHD 3T MRI were recruited. Images were acquired and reconstructed using methods A\u2013D. Two cardiovascular radiologists independently scored the images on a 5\u2010point scale. These readers performed a paired wall motion and functional assessment between method D and 2D balanced steady\u2010state free precession (bSSFP) CINE for 16 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Method D had higher diagnostic image quality for most anatomical features (mean 3.8\u20134.8) compared to A (2.0\u20133.6), B (2.2\u20133.7), and C (2.9\u20133.9) with <jats:italic>P<\/jats:italic> &lt; 0.05 with good interobserver agreement (<jats:italic>\u03ba<\/jats:italic> \u2265 0.49). Method D had similar or better assessment of myocardial borders and cardiac motion compared to 2D bSSFP (<jats:italic>P<\/jats:italic> &lt; 0.05, <jats:italic>\u03ba<\/jats:italic> \u2265 0.77). All methods had good internal agreement in comparing aortic with pulmonic flow (BA mean &lt; 0.02%, <jats:italic>r<\/jats:italic> &gt; 0.85) and compared to method A (BA mean &lt; 0.13%, <jats:italic>r<\/jats:italic> &gt; 0.84) with <jats:italic>P<\/jats:italic> &lt; 0.01.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flow, functional, and anatomical assessment in CHD with ferumoxytol\u2010enhanced 4D flow is feasible and can be significantly improved using motion compensation and compressed sensing. J. Magn. Reson. 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