{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:40:19Z","timestamp":1781635219587,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the use of diffusion\u2010weighted imaging (DWI) for differentiating acute from chronic cholecystitis, in comparison with conventional magnetic resonance imaging (MRI) features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Liver MRI including DWI (b\u2010values 0\/500\/1000s\/mm<jats:sup>2<\/jats:sup>) was performed at 1.5T \u226430 days before cholecystectomy in 83 patients with abdominal pain. Two radiologists assessed cases for conventional (gallstones, wall thickening, pericholecystic fluid, pericholecystic fat changes, gallbladder distension, pericholecystic liver enhancement, mural <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010hyperintensity, mural hyperenhancement, mural striations, abscess, intraluminal membranes, and mural defect) and DWI (increased mural signal on high b\u2010value images, visually low apparent diffusion coefficient [ADC], and ADC values) features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute cholecystitis was present in 43%; chronic cholecystitis was present in 57%. Nine of 12 conventional features were more frequent in acute cholecystitis for both readers (<jats:italic>P<\/jats:italic> \u2264 0.003). Increased mural signal on high b\u2010value images was more frequent (<jats:italic>P<\/jats:italic> &lt; 0.001) in acute than chronic cholecystitis for R1 (92% vs. 32%) and R2 (83% vs. 30%). Sensitivity and specificity of increased signal on high b\u2010value images were: R1, 92%\/68%; R2, 83%\/70%. Visually low ADC was more frequent in acute cholecystitis for R2 (<jats:italic>P<\/jats:italic> &lt; 0.001) but not R1 (<jats:italic>P<\/jats:italic>\u2009=\u20090.406); ADC values were not different between groups for either reader (<jats:italic>P<\/jats:italic>\u2009=\u20090.104\u20130.139). Among conventional and DWI features, only increased signal on high b\u2010value DWI was independently associated with acute cholecystitis for both readers (<jats:italic>P<\/jats:italic>\u2009=\u20090.006\u20130.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Visually increased mural signal on high b\u2010value DWI was highly sensitive and moderately specific for acute cholecystitis, being an independent predictor relative to conventional features for both readers. Although requiring larger studies, DWI (particularly the high b\u2010value images) may have additive value relative to conventional MRI\u2010suspected acute cholecystitis. J. Magn. Reson. Imaging 2016;44:89\u201397.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25128","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T12:54:09Z","timestamp":1450788849000},"page":"89-97","source":"Crossref","is-referenced-by-count":22,"title":["Utility of diffusion\u2010weighted MRI for differentiating acute from chronic cholecystitis"],"prefix":"10.1002","volume":"44","author":[{"given":"Annie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology NYU School of Medicine, NYU Langone Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alampady K.","family":"Shanbhogue","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU School of Medicine, NYU Langone Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Dunst","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU 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