{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:18:55Z","timestamp":1770697135942,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare perfusion\u2010free to perfusion\u2010sensitive measurements of the apparent diffusion coefficient (ADC) to diagnose benign conditions from malignancies of the anterior mediastinum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Seventy\u2010six subjects were divided into a \u201cbenign conditions\u201d group (A, <jats:italic>n<\/jats:italic> = 44) and a \u201cmalignancies\u201d group (B, <jats:italic>n<\/jats:italic> = 32), based on histological findings. diffusion\u2010weighted magnetic resonance imaging (DW\u2010MRI) was performed at <jats:italic>b<\/jats:italic> of 0\/150\/800 sec\/mm<jats:sup>2<\/jats:sup>. The ADCs were obtained on an ADC map by including (perfusion\u2010sensitive = ADC<jats:sub>b0\u2010800<\/jats:sub>) and excluding (perfusion\u2010free = ADC<jats:sub>b150\u2010800<\/jats:sub>) the <jats:italic>b<\/jats:italic> = 0 sec\/mm<jats:sup>2<\/jats:sup>. The Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test was used to detect differences in ADC<jats:sub>b0\u2010800<\/jats:sub> compared with ADC<jats:sub>b150\u2010800<\/jats:sub> values between all cases, benign conditions, and malignancies. The same test was used to evaluate differences in ADCs between the two groups for each type of measurement (ADC<jats:sub>b0\u2010800<\/jats:sub> and ADC<jats:sub>b150\u2010800<\/jats:sub>), and receiver\u2010operating characteristic (ROC) curves were obtained to evaluate discrimination abilities with comparison of areas\u2010under\u2010ROC\u2010curves (AUROC). Optimal cutpoints for discrimination between groups were determined by the Youden\u2010Index with computation of accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median ADC<jats:sub>b0\u2010800<\/jats:sub> was significantly greater compared with ADC<jats:sub>b150\u2010800<\/jats:sub> for all cases (<jats:italic>P<\/jats:italic> = 0.0014), benign conditions (<jats:italic>P<\/jats:italic> = 0.0412), and malignancies (<jats:italic>P<\/jats:italic> = 0.0001). The median percentage of increase was 5.30% for group\u2010A and 22.39% for group\u2010B (<jats:italic>P<\/jats:italic> &lt; 0.0001). AUROC of ADC in discriminating between groups was significantly greater for ADC<jats:sub>b150\u2010800<\/jats:sub> (0.932) compared with ADC<jats:sub>b0\u2010800<\/jats:sub> (0.831) (<jats:italic>P<\/jats:italic> = 0.001). The optimal cutpoint for distinction between groups was 1.52 \u00d7 10<jats:sup>\u20103<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/sec (sensitivity = 93.7%, specificity = 88.6%, accuracy = 90.8%) for ADC<jats:sub>b150\u2010800<\/jats:sub> and 1.75 \u00d7 10<jats:sup>\u20103<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/sec (sensitivity = 75.0%, specificity = 79.5%, accuracy = 77.6%) for ADC<jats:sub>b0\u2010800<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of perfusion\u2010free ADC measurements significantly improves diagnostic accuracy of DW\u2010MRI in differentiating benign conditions from malignancies of the anterior mediastinum. J. Magn. Reson. Imaging 2016;44:758\u2013769.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25203","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T15:37:34Z","timestamp":1455982654000},"page":"758-769","source":"Crossref","is-referenced-by-count":18,"title":["Diffusion\u2010weighted quantitative MRI to diagnose benign conditions from malignancies of the anterior mediastinum: Improvement of diagnostic accuracy by comparing perfusion\u2010free to perfusion\u2010sensitive measurements of the apparent diffusion coefficient"],"prefix":"10.1002","volume":"44","author":[{"given":"Adriano Massimiliano","family":"Priola","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro Massimo","family":"Priola","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Gned","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Piacibello","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Sardo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Parvis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hematology San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Torti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hematology San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ardissone","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Veltri","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging San Luigi Gonzaga University Hospital Orbassano (Torino) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2010.03.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.11.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23947"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22786"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23643"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22838"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.81328"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101821"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2293-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.07.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2014.01.005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2014.05.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000056"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.0041"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010015\u20104031\u20106"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131643"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185114554254"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21850"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21871"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2180-9"},{"key":"e_1_2_6_22_1","first-page":"52","article-title":"Differentiation of lymphoma versus sarcoidosis in the setting of mediastinal\u2010hilar lymphadenopathy: assessment with diffusion\u2010weighted MR imaging","volume":"30","author":"G\u00fcm\u00fcstas S","year":"2013","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.08.002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.03.008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-3054-0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.01.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000120"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-015-0434-1"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000095"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2390-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14141528"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2433060797"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0357-7"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132665"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5515"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1403"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-006-0031-6"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:28:51Z","timestamp":1696375731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/jmri.25203"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25203","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}