{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:04:19Z","timestamp":1778555059958,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81201070"],"award-info":[{"award-number":["81201070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fudan University Foundation for Young Teachers to Improve Scientific Research Ability","award":["20520133486"],"award-info":[{"award-number":["20520133486"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether myocardial extracellular volume fraction (ECV) measurement by cardiac MR is indicative of myocardial injury, angiographic collateral flow, and functional recovery in patients with chronic total coronary occlusion (CTO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 50 CTO patients undergoing 1.5 Tesla MR were prospectively enrolled, and 28 underwent a second MR 6 months after revascularization. T1\u2010mapping based indices, including pre\u2010 and postcontrast T1 values and ECV, were obtained from infarcted and non\u2010infarcted myocardium, myocardial segments, and coronary territory. The severity of myocardial injury was rated by transmurality extent of infarction (TEI) and regional wall motion abnormalities (RWMA) score. Angiographic collateral flow was evaluated using Rentrop classification. Improvement in segmental wall motion at 6 months was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ECV and postcontrast T1 value significantly outperformed precontrast T1 value for identifying myocardial infarction (area under the receiver operating characteristic curve [AUC]: 0.998 and 0.953 versus 0.824, all <jats:italic>P<\/jats:italic> &lt; 0.02). Myocardial ECV was strongly correlated with TEI (<jats:italic>P<\/jats:italic> = 0.000), RWMA score (<jats:italic>P<\/jats:italic> = 0.000), and collateral classification (<jats:italic>P<\/jats:italic> = 0.007 for left anterior descending artery [LAD] territory, <jats:italic>P<\/jats:italic> = 0.001 for non\u2010LAD territory). Furthermore, the likelihood of functional recovery was better predicted by ECV than by late gadolinium enhancement (LGE) (AUC: 0.76 versus 0.68, <jats:italic>P<\/jats:italic> &lt; 0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myocardial ECV may be a useful surrogate to assess myocardial injury and angiographic collateral flow in CTO, and ECV provides incremental value to LGE in assessing functional recovery after revascularization. J. MAGN. RESON. IMAGING 2016;44:972\u2013982.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25235","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T13:42:44Z","timestamp":1458740564000},"page":"972-982","source":"Crossref","is-referenced-by-count":10,"title":["Myocardial extracellular volume fraction measurement in chronic total coronary occlusion: Association with myocardial injury, angiographic collateral flow, and functional recovery"],"prefix":"10.1002","volume":"44","author":[{"given":"Yin\u2010yin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology Zhongshan Hospital Fudan University Department of Medical Imaging Shanghai Medical school Fudan University and Shanghai Institute of Medical Imaging Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dao\u2010yuan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital Fudan University and Shanghai 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