{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:10:55Z","timestamp":1790475055232,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scoliosis Research Society (New Investigator Grant)"},{"name":"Fonds de Recherche du Qu\u00e9bec en Nature et Technologies (Grant Etablissement de nouveaux chercheurs universitaires)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To measure magnetic resonance imaging (MRI) parameters including relaxation times (<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>), magnetization transfer (MT) and diffusion parameters (mean diffusivity [MD], fractional anisotropy [FA]) of intervertebral discs in adolescents with idiopathic scoliosis, and to investigate the sensitivity of these MR parameters to the severity of the spine deformities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirteen patients with adolescent idiopathic scoliosis and three control volunteers with no history of spine disease underwent an MRI acquisition at 3T including the mapping of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u03c1, <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>, MT, MD, and FA. The apical zone included all discs within the scoliotic curve while the control zone was composed of other discs. The severity was analyzed through low (&lt;32\u00b0) versus high (&gt;40\u00b0) Cobb angles. One\u2010way analysis of variance (ANOVA) and agglomerative hierarchical clustering (AHC) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were found between the apical zone and the control zone for <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> = 0.047), and between low and high Cobb angles for <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> = 0.014) and MT (<jats:italic>P<\/jats:italic> = 0.002). AHC showed two distinct clusters, one with mainly low Cobb angles and one with mainly high Cobb angles, for the MRI parameters measured within the apical zone, with an accuracy of 0.9 and a Matthews correlation coefficient (MCC) of 0.8. Within the control zone, the AHC showed no clear classification (accuracy of 0.6 and MCC of 0.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We successfully performed an in vivo multiparametric MRI investigation of young patients with adolescent idiopathic scoliosis. The MRI parameters measured within the intervertebral discs were found to be sensitive to intervertebral disc degeneration occurring with scoliosis and to the severity of scoliosis.  J. Magn. Reson. 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