{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:28:57Z","timestamp":1792841337568,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:00:00Z","timestamp":1460678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To longitudinally evaluate the cortical thickness and deep gray matter structures volume, measured from T1 three\u2010dimensional (3D) Gradient echo\u2010weighted imaging, and white matter integrity, assessed from diffusion tensor imaging (DTI) of HIV\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010one HIV\u2010positive patients on stable highly active antiretroviral therapy (HAART) with CD4+ T lymphocytes count &gt;200 cells\/mL and viral load &lt;50 copies\/mL underwent two magnetic resonance imaging (MRI) scans with a median interval of 26.6 months. None of the patients had HIV\u2010related dementia. T1 3D magnetization prepared rapid gradient echo\u2010weighted imaging and DTI along 30 noncolinear directions were performed using a 1.5 Tesla MR scanner. FreeSurfer was used to perform cortical volumetric reconstruction and segmentation of deep gray matter structures. For tract\u2010based spatial statistics analysis, a white matter skeleton was created, and a permutation\u2010based inference with 5000 permutations, with a threshold of <jats:italic>P<\/jats:italic> &lt; 0.05 was used to identify abnormalities in fractional anisotropy (FA). The median, radial, and axial diffusivities were also projected onto the mean FA skeleton.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in cortical thickness, deep gray matter structures volumes or diffusivity parameters between scans at the two time points (considering <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No longitudinal differences in cortical thickness, deep gray matter volumes, or white matter integrity were observed in an HIV\u2010positive population on stable HAART, with undetectable viral load and high CD4+ T lymphocytes count. J. Magn. Reson. Imaging 2016;44:1262\u20131269.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25263","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T05:36:06Z","timestamp":1460698566000},"page":"1262-1269","source":"Crossref","is-referenced-by-count":30,"title":["Longitudinal assessment of subcortical gray matter volume, cortical thickness, and white matter integrity in HIV\u2010positive patients"],"prefix":"10.1002","volume":"44","author":[{"given":"Diogo Goulart","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Department of Radiology Hospital Universit\u00e1rio Clementino Fraga Filho, Federal University of Rio de Janeiro, Cidade Universit\u00e1ria, Ilha do Fund\u00e3o Rio de Janeiro RJ Brazil"},{"name":"Cl\u00ednica de Diagn\u00f3stico por Imagem (CDPI), Barra da Tijuca Rio de Janeiro RJ 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