{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:04:00Z","timestamp":1790751840048,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project Grants from the Chief Scientist Office (SC01)"},{"name":"Medical Research Scotland (343 FRG)"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["BHF-PG\/14\/64\/31043"],"award-info":[{"award-number":["BHF-PG\/14\/64\/31043"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fellowship from the British Heart Foundation","award":["FS\/15\/54\/31639"],"award-info":[{"award-number":["FS\/15\/54\/31639"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess myocardial strain using cine displacement encoding with stimulated echoes (DENSE) using 1.5T and 3.0T MRI in healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Healthy adults without any history of cardiovascular disease underwent magnetic resonance imaging (MRI) at 1.5T and 3.0T within 2 days. The MRI protocol included balanced steady\u2010state free\u2010precession (b\u2010SSFP), 2D cine\u2010echo planar imaging (EPI)\u2010DENSE, and late gadolinium enhancement in subjects &gt;45 years. Acquisitions were divided into six segments; global and segmental peak longitudinal and circumferential strain were derived and analyzed by field strength, age, and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 89 volunteers (mean age 44.8 \u00b1 18.0 years, range: 18\u201387 years) underwent MRI at 1.5T, and 88 of these subjects underwent MRI at 3.0T (1.4 \u00b1 1.4 days between the scans). Compared with 3.0T, the magnitudes of global circumferential (\u201319.5 \u00b1 2.6% vs. \u201318.47 \u00b1 2.6%; <jats:italic>P<\/jats:italic> = 0.001) and longitudinal (\u201312.47 \u00b1 3.2% vs. \u201310.53 \u00b1 3.1%; <jats:italic>P<\/jats:italic> = 0.004) strain were greater at 1.5T. At 1.5T, longitudinal strain was greater in females than in males: \u201310.17 \u00b1 3.4% vs. \u201313.67 \u00b1 2.4%; <jats:italic>P<\/jats:italic> = 0.001. Similar observations occurred for circumferential strain at 1.5T (\u201318.72 \u00b1 2.2% vs. \u201320.10 \u00b1 2.7%; <jats:italic>P<\/jats:italic> = 0.014) and at 3.0T (\u201317.92 \u00b1 1.8% vs. \u201319.1 \u00b1 3.1%; <jats:italic>P<\/jats:italic> = 0.047). At 1.5T, longitudinal and circumferential strain were not associated with age after accounting for sex (longitudinal strain <jats:italic>P<\/jats:italic> = 0.178, circumferential strain <jats:italic>P<\/jats:italic> = 0.733). At 3.0T, longitudinal and circumferential strain were associated with age (<jats:italic>P<\/jats:italic> &lt; 0.05). Longitudinal strain values were greater in the apico\u2010septal, basal\u2010lateral, and mid\u2010lateral segments and circumferential strain in the inferior, infero\u2010lateral, and antero\u2010lateral LV segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myocardial strain parameters as revealed by cine\u2010DENSE at different MRI field strengths were associated with myocardial region, age, and sex. J. Magn. Reson. Imaging 2016;44:1197\u20131205.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25280","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T23:10:52Z","timestamp":1461366652000},"page":"1197-1205","source":"Crossref","is-referenced-by-count":30,"title":["Myocardial strain in healthy adults across a broad age range as revealed by cardiac magnetic resonance imaging at 1.5 and 3.0T: Associations of myocardial strain with myocardial region, age, and sex"],"prefix":"10.1002","volume":"44","author":[{"given":"Kenneth","family":"Mangion","sequence":"first","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre University of Glasgow  UK"},{"name":"West of Scotland Heart and Lung Centre Golden Jubilee National Hospital Clydebank UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Clerfond","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre University of Glasgow  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