{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:44:35Z","timestamp":1790646275870,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23\u2010AR059748"],"award-info":[{"award-number":["K23\u2010AR059748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1\u2010AR066008"],"award-info":[{"award-number":["RO1\u2010AR066008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To use 7T magnetic resonance imaging (MRI) to determine how trabecular bone microarchitecture varies at the epiphysis, metaphysis, and diaphysis of the distal radius.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The distal radius of 24 females (mean age\u2009=\u200956 years, range\u2009=\u200924\u201378 years) was scanned on a 7T MRI using a 3D fast low\u2010angle shot sequence (0.169 \u00d7 0.169 \u00d7 1\u2009mm). Digital topological analysis was applied at the epiphysis, metaphysis, and diaphysis to compute: total trabecular bone volume; trabecular thickness, number, connectivity, and erosion index (a measure of network resorption). Differences and correlations were assessed using standard statistical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The metaphysis and epiphysis had 83\u2013123% greater total bone volume and 14\u201316% greater trabecular number than the diaphysis (both <jats:italic>P<\/jats:italic> &lt; 0.0001). The erosion index was significantly higher at the diaphysis than the metaphysis and epiphysis (both <jats:italic>P<\/jats:italic> &lt; 0.01). The most elderly volunteers had lower trabecular number (&lt;66 years mean 0.29\u2009\u00b1\u20090.01; \u226566 years, 0.27\u2009\u00b1\u20090.02, <jats:italic>P<\/jats:italic> &lt; 0.05) and higher erosion index (&lt;66 years mean 1.18\u2009\u00b1\u20090.17; age \u226566 years, mean 1.42\u2009\u00b1\u20090.46, <jats:italic>P<\/jats:italic> &lt; 0.05) at the epiphysis; differences not detected by total trabecular bone volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>7T MRI reveals trabecular bone microarchitecture varies depending on scan location at the end\u2010of\u2010bone, being of overall higher quality distally (epiphysis) than proximally (diaphysis). Age\u2010related differences in trabecular microarchitecture can be detected by 7T MRI. The results highlight the potential sensitivity of 7T MRI to microarchitectural differences and the potential importance of standardizing scan location for future clinical studies of fracture risk or treatment response.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;45:872\u2013878.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25398","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T13:54:44Z","timestamp":1469022884000},"page":"872-878","source":"Crossref","is-referenced-by-count":11,"title":["7T MRI of distal radius trabecular bone microarchitecture: How trabecular bone quality varies depending on distance from end\u2010of\u2010bone"],"prefix":"10.1002","volume":"45","author":[{"given":"Lindsay M.","family":"Griffin","sequence":"first","affiliation":[{"name":"Department of Radiology New York University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Honig","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punam K.","family":"Saha","sequence":"additional","affiliation":[{"name":"University of Iowa Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Regatte","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology New York University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08761-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00614-7"},{"key":"e_1_2_7_4_1","volume-title":"Bone health and osteoporosis: A report of the surgeon general","year":"2004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08657-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2010.02.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.02.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20807"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.6.837"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050221"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.3.r00dc06855"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.206.2.9457185"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1258"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0140-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080108"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22072"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-011-0252-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/cviu.1996.0032"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1098(2000)11:1<81::AID-IMA9>3.0.CO;2-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554913"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00439050"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-010-0243-6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02546396"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.1.111"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090317"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1780-5"},{"key":"e_1_2_7_29_1","unstructured":"Distal radius fractures (broken wrist) (March 2013).Orthoinfo.aaos.org. 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