{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:40:32Z","timestamp":1777632032198,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate if diffusion tensor imaging MR neurography (DTI\u2010MRN) can detect lesions of peripheral nerves in patients with type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eleven type 1 diabetic patients with polyneuropathy (DPN), 10 type 1 diabetic patients without polyneuropathy (nDPN), and 10 healthy controls (HC) were investigated with a 3T MRI scanner. Clinical examinations, nerve\u2010conduction studies, and vibratory\u2010perception thresholds determined the presence of DPN. DTI\u2010MRN (voxel size: 1.4 \u00d7 1.4 \u00d7 3\u2009mm<jats:sup>3<\/jats:sup>; b\u2010values: 0, 800 s\/mm<jats:sup>2<\/jats:sup>) covered proximal (sciatic nerve) and distal regions of the lower extremity (tibial nerve). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated and compared to <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010relaxometry and proton\u2010spin density obtained from a multiecho turbo spin echo (TSE) sequence. Furthermore, we evaluated DTI reproducibility, repeatability, and diagnostic accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DTI\u2010MRN could accurately discriminate between DPN, nDPN, and HC. The proximal FA was lowest in DPN (DPN 0.37\u2009\u00b1\u20090.06; nDPN 0.47\u2009\u00b1\u20090.03; HC 0.49\u2009\u00b1\u20090.06; <jats:italic>P<\/jats:italic> &lt; 0.01). In addition, distal FA was lowest in DPN (DPN 0.31\u2009\u00b1\u20090.05; nDPN 0.41\u2009\u00b1\u20090.07; HC 0.43\u2009\u00b1\u20090.08; <jats:italic>P<\/jats:italic> &lt; 0.01). Likewise, proximal ADC was highest in DPN (DPN 1.69\u2009\u00b1\u20090.25 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s; nDPN 1.50\u2009\u00b1\u20090.06 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s; HC 1.42\u2009\u00b1\u20090.12 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s; <jats:italic>P<\/jats:italic> &lt; 0.01) as was distal ADC (DPN 1.87\u2009\u00b1\u20090.45 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s; nDPN 1.59\u2009\u00b1\u20090.19 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s; HC 1.57\u2009\u00b1\u20090.26 \u00d7 10<jats:sup>\u22123<\/jats:sup>mm<jats:sup>2<\/jats:sup>\/s; <jats:italic>P<\/jats:italic>\u2009=\u20090.09). The combined interclass\u2010correlation (ICC) coefficient of DTI reproducibility and repeatability was high in the sciatic nerve (ICC: FA\u2009=\u20090.86; ADC\u2009=\u20090.85) and the tibial nerve (ICC: FA\u2009=\u20090.78; ADC\u2009=\u20090.66). <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010relaxometry and proton\u2010spin\u2010density did not enable detection of neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DTI\u2010MRN accurately detects DPN by lower nerve FA and higher ADC. These alterations are likely to reflect proximal and distal nerve fiber pathology.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;45:1125\u20131134<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25415","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T07:46:40Z","timestamp":1489564000000},"page":"1125-1134","source":"Crossref","is-referenced-by-count":44,"title":["Diffusion tensor imaging MR neurography for the detection of polyneuropathy in type 1 diabetes"],"prefix":"10.1002","volume":"45","author":[{"given":"Michael","family":"Vaeggemose","sequence":"first","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"},{"name":"Danish Diabetes Academy Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Ringgaard","sequence":"additional","affiliation":[{"name":"MR Research Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Tankisi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Ejskjaer","sequence":"additional","affiliation":[{"name":"Clinical Research Science Park Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Heiland","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per L.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1226"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0739"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2010.29.5.697"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1491"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24524"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu344"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000128"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.6012"},{"key":"e_1_2_5_10_1","unstructured":"AllanH. 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