{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:59:48Z","timestamp":1790110788512,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Medical Imaging at Hospital Oost-Limburg, Genk, Belgium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To prospectively evaluate and compare the junctional zone (JZ) and outer myometrial thickness in infertile and healthy nulliparous women at different locations in the uterine wall during the menstrual cycle by magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We performed pelvic 1.5T MRI (<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted turbo spin echo sequences) on 28 infertile women: 5 with infertility of unknown origin, 12 anovulating, and 11 on ovarian stimulation therapy (mean age 28.5, 30.8, and 29.3 years, respectively); and a control group consisting of 18 healthy nulliparous volunteers (mean age 26.4 years). The women with unknown infertility origin and the control group underwent MRI investigations during their follicular, ovulatory, and luteal phase. The JZ and outer myometrial thicknesses were measured at six locations in the uterine wall: anterior and posterior wall of the isthmus, midcorpus, and fundus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The JZ in the anovulating women at the posterior wall of the isthmus (4.2\u2009mm) was significantly thicker compared to the control group (3.2, 3.0, and 2.9\u2009mm, in respectively the three menstrual phases) (<jats:italic>P<\/jats:italic>\u2009=\u20090.027). The outer myometrium in the anovulating women was significantly thicker at all measured locations (average 11.5\u2009mm) in comparison to the control group (8.1, 8.0, and 8.5\u2009mm, in respectively the three menstrual phases) (<jats:italic>P<\/jats:italic> &lt; 0.050). The infertile women on ovarian stimulation therapy showed a significantly thicker outer myometrium at the anterior wall (isthmus, midcorpus, and fundus) (<jats:italic>P<\/jats:italic> &lt; 0.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicate that a thickened JZ, and especially a thickened outer myometrium, might be associated with infertility.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;45:926\u2013936.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25422","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T16:16:42Z","timestamp":1471537002000},"page":"926-936","source":"Crossref","is-referenced-by-count":15,"title":["Uterine junctional zone thickness in infertile women evaluated by MRI"],"prefix":"10.1002","volume":"45","author":[{"given":"Liesbeth J.","family":"Meylaerts","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Ziekenhuis Oost\u2010Limburg Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Ziekenhuis Oost\u2010Limburg Genk Belgium"},{"name":"Faculty of Medicine and Biomedicine Hasselt University Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Ombelet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Ziekenhuis Oost\u2010Limburg Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bazot","sequence":"additional","affiliation":[{"name":"Department of Radiology H\u00f4pital Tenon Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Vandersteen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedicine Hasselt University Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"445","article-title":"Infertility: a global perspective","volume":"58","author":"Benagiano G","year":"2006","journal-title":"Minerva Ginecol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.02.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.1.190"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/11.3.627"},{"key":"e_1_2_8_7_1","first-page":"409","volume-title":"Endocrine basis of reproductive function","author":"Kunz G","year":"2000"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54246-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01189.x"},{"issue":"7","key":"e_1_2_8_10_1","first-page":"5S30","article-title":"Uterine factors limiting ART coverage","volume":"34","author":"Piver P","year":"2005","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60207-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.10.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.141.6.1119"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1120"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4877"},{"key":"e_1_2_8_17_1","first-page":"86","article-title":"Estimation of nongravid uterine volume based on a nomogram of gravid uterine volume: its value in gynecologic uterine abnormalities","volume":"72","author":"Goldstein SR","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.160.1.3715022"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0313-3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.2.3532190"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.4.337"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.suppl_1.g99oc13s147"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep474"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.11.065"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-813644"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.166.5.8615259"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.01.015"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.199.1.8633139"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.11.2427"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0494-9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-011-9640-7"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:22:46Z","timestamp":1695536566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,18]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/jmri.25422"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25422","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,18]]}}}