{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:55:55Z","timestamp":1790326555915,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571661"],"award-info":[{"award-number":["81571661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the accuracy of the <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation time index on gadoxetic acid\u2010enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B (CHB), in comparison and combination with the aspartate aminotransferase\u2010to\u2010platelet ratio index (APRI) and fibrosis\u20104 (FIB\u20104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective study of gadoxetic acid\u2010enhanced <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> mapping and serum biochemical tests was performed on 126 CHB patients who underwent gadoxetic acid\u2010enhanced 1.5T MRI, and the histological score used as the gold standard. The reduction rate of <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation time before and 20 minutes after gadoxetic acid injection (\u0394<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>, \u0394R1%), the contrast uptake rate (K<jats:sub>Hep<\/jats:sub>), APRI, and FIB\u20104 were calculated. The diagnostic efficacy of \u0394<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>, \u0394R1%, K<jats:sub>Hep<\/jats:sub>, APRI, and FIB\u20104 for predicting stage 2 or greater (\u2265S2), stage 3 or greater (\u2265S3), and stage 4 (S4) was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u0394<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.513, <jats:italic>P<\/jats:italic> &lt; 0.001), \u0394R1% (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.626, <jats:italic>P<\/jats:italic> &lt; 0.001), K<jats:sub>Hep<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.527, <jats:italic>P<\/jats:italic> &lt; 0.001), APRI (<jats:italic>r<\/jats:italic>\u2009=\u20090.519, <jats:italic>P<\/jats:italic> &lt; 0.001), and FIB\u20104 (<jats:italic>r<\/jats:italic>\u2009=\u20090.476, <jats:italic>P<\/jats:italic> &lt; 0.001) correlated significantly with fibrosis stages. Areas under the curves (AUCs) of \u0394R1% for detecting \u2265S2, \u2265S3, and S4 were 0.849, 0.827, and 0.809, which were greater than that of APRI (0.763, 0.745, 0.787) and FIB\u20104 (0.727, 0.738, 0.772), but significant difference was found only in discriminating \u2265S2 between \u0394R1% and FIB\u20104 (<jats:italic>P<\/jats:italic>\u2009=\u20090.027). The combination of all five indices performed best, with AUC, sensitivity, and specificity of 0.860, 87.21%, and 72.50% for diagnosing \u2265S2, 0.878, 82.81%, and 85.48% for \u2265S3, and 0.867, 80.00%, and 83.95% for S4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The gadoxetic acid\u2010enhanced <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> relaxation time index appears to be superior to APRI and FIB\u20104 for predicting hepatic fibrosis. The combined use of gadoxetic acid\u2010enhanced <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> mapping, APRI, and FIB\u20104 may be more reliable for staging liver fibrosis in CHB.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 4<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;45:1186\u20131194<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25440","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T17:53:25Z","timestamp":1472234005000},"page":"1186-1194","source":"Crossref","is-referenced-by-count":29,"title":["Staging liver fibrosis in chronic hepatitis B with <i>T<\/i><sub>1<\/sub> relaxation time index on gadoxetic acid\u2010enhanced MRI: Comparison with aspartate aminotransferase\u2010to\u2010platelet ratio index and FIB\u20104"],"prefix":"10.1002","volume":"45","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai P.R. China"},{"name":"Department of Radiology Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiang","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai P.R. China"},{"name":"Department of Radiology Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caizhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofan","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai P.R. China"},{"name":"Department of Radiology Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Fu","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University Shanghai P.R. China"},{"name":"Department of Radiology Zhongshan Hospital, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4263"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27382"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2452061673"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100621"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070077"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2249-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140313"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23691"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.01.031"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10092065"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122482"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24529"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.06.013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25288"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.12.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12092"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3542-x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2302-4"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-3086-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016151229"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140828"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.020073"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2583-2"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070114"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12590"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12010"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.05.007"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.1.1549695"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301020269"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.018"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:48:47Z","timestamp":1694666927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/jmri.25440"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25440","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]}}}