{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:22:00Z","timestamp":1785356520220,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01\u2010AR068373\u201001"],"award-info":[{"award-number":["R01\u2010AR068373\u201001"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the feasibility of using compressed sensing (CS) to accelerate three\u2010dimensional fast spin\u2010echo (3D\u2010FSE) imaging of the knee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A 3D\u2010FSE sequence was performed at 3T with CS (CUBE\u2010CS with 3:16\u2010minute scan time) and without CS (CUBE with 4:44\u2010minute scan time) twice on the knees of 10 healthy volunteers to assess signal\u2010to\u2010noise ratio (SNR) using the addition\u2010subtraction method and once on the knees of 50 symptomatic patients to assess diagnostic performance. SNR of cartilage, muscle, synovial fluid, and bone marrow on CUBE and CUBE\u2010CS images were measured in the 10 healthy volunteers. The CUBE and CUBE\u2010CS sequences of all 50 symptomatic patients were independently reviewed twice by two musculoskeletal radiologists. The radiologists used CUBE and CUBE\u2010CS during each individual review to determine the presence or absence of knee joint pathology. Student's <jats:italic>t<\/jats:italic>\u2010tests were used to compare SNR values between sequences, while the kappa statistic was used to determine agreement between sequences for detecting knee joint pathology. Sensitivity and specificity of CUBE and CUBE\u2010CS for detecting knee joint pathology was also calculated in the 18 symptomatic patients who underwent subsequent arthroscopic knee surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CUBE and CUBE\u2010CS had similar SNR (<jats:italic>P<\/jats:italic>\u2009=\u20090.15\u20130.67) of cartilage, muscle, synovial fluid, and bone marrow. There was near\u2010perfect to perfect agreement between CUBE and CUBE\u2010CS for both radiologists for detecting cartilage and bone marrow edema lesions, medial and lateral meniscus tears, anterior cruciate ligament tears, effusions, and intra\u2010articular bodies. CUBE and CUBE\u2010CS had similar sensitivity (75.0\u2013100%) and specificity (87.5\u2013100%) for detecting 60 cartilage lesions, 20 meniscus tears, four anterior cruciate ligament tears, and four intra\u2010articular bodies confirmed at surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CS provided a 30% reduction in scan time for 3D\u2010FSE imaging of the knee without a corresponding decrease in SNR or diagnostic performance.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p>J. MAGN. RESON. 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