{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:29:33Z","timestamp":1778048973990,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate magnetic resonance imaging (MRI) for assessment of extraprostatic extension (EPE) and positive surgical margins (PSM) in anterior prostate cancer (APC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>With Institutional Review Board approval, 25 APC (&gt;2\/3 of tumor anterior to urethra) were assessed using 3T MRI by two blinded radiologists for: size and maximal leading edge of tumor (relative to anterior fibromuscular stroma [AFMS]) on b \u22651000 sec\/mm<jats:sup>2<\/jats:sup> echo\u2010planar\u2010MRI fused onto <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010weighted\u2010MRI, invasion of AFMS and EPE. Comparisons were performed between APCs by EPE\/PSM using chi\u2010square, multivariable analysis, and receiver operator characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of EPE and PSM were 52% (13\/25) and 36% (9\/25). Tumor sizes were larger with EPE (22.5\u2009\u00b1\u20098.4 vs. 14.7\u2009\u00b1\u20096.3, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and PSM (23.0\u2009\u00b1\u20099.3 vs. 16.4\u2009\u00b1\u20097.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.06). Area under ROC curve (AUC\u2010ROC) for the diagnosis of EPE by tumor size was 0.77 (95% confidence interval [CI] 0.58\u20130.95); \u226516\u2009mm size\u2009=\u2009sensitivity\/specificity 69.2\/66.7%. Maximal leading edge of tumor was greater with EPE (2.4\u2009\u00b1\u20092.2 vs. \u20130.2\u2009\u00b1\u20093.0) and PSM (2.8\u2009\u00b1\u20092.3 vs. \u20130.3\u2009\u00b1\u20092.5), (<jats:italic>P<\/jats:italic>\u2009=\u20090.023, 0.031). AUC\u2010ROC for diagnosis of EPE\/PSM by leading edge was 0.78 (CI 0.57\u20130.97) and 0.75 (CI 0.56\u20130.94). A \u22651\u2009mm leading edge yielded sensitivity\/specificity of 76.9\/75.0% and 77.8\/62.5% for diagnosis of EPE\/PSM. 60\u201372% (15\u201318\/25) tumors invaded AFMS (k\u2009=\u20090.74), which was not associated with EPE\/PSM (<jats:italic>P<\/jats:italic>\u2009=\u20090.12\u20130.14). Radiologists' assessment of EPE had sensitivity\/specificity of 61.5\u201369.2\/50.0\u201375.0% (k\u2009=\u20090.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tumor size and leading edge of tumor relative to AFMS may enable diagnosis of EPE and positive surgical margins in APC.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p>J. MAGN. RESON. IMAGING 2017;45:1296\u20131303<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25510","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T15:08:20Z","timestamp":1476371300000},"page":"1296-1303","source":"Crossref","is-referenced-by-count":17,"title":["MRI assessment of pathological stage and surgical margins in anterior prostate cancer (APC) using subjective and quantitative analysis"],"prefix":"10.1002","volume":"45","author":[{"given":"Nicola","family":"Schieda","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Ottawa Hospital University of Ottawa Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Ottawa Hospital University of Ottawa Ottawa Ontario 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