{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:40:03Z","timestamp":1777736403866,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the apparent diffusion coefficient (ADC) values between multiple sclerosis (MS) and neuromyelitis optica (NMO)\u2010related acute optic neuritis (ON) patients and predict their optic nerve atrophy of optic coherence tomography (OCT) parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Nineteen MS and 15 NMO\u2010related acute ON patients who underwent a diffusion\u2010weighted imaging sequence in 3.0 Tesla MR scanner and a follow\u2010up OCT examination after 6 months were included. The ADC values, thickness of the retinal nerve fiber layer (RNFL) and the macular ganglion cell complex (GCC) between MS and NMO related ON were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean ADC value of the NMO\u2010ON, (0.691\u2009\u00b1\u20090.195[SD])\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, was significantly smaller (<jats:italic>P<\/jats:italic>\u2009=\u20090.0133) than that of MS\u2010ON. The mean ADC value of MS\u2010ON, (0.879\u2009\u00b1\u20090.144)\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, was significantly smaller (<jats:italic>P<\/jats:italic> &lt; 0.0001) than that of control group, (1.025\u2009\u00b1\u20090.067)\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s. Using an ADC value smaller than 0.830\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s as the threshold value for differentiating MS\u2010ON from NMO\u2010ON patients, the highest accuracy of 76.7%, with 75.0% sensitivity and 78.3% specificity, was obtained. The ADC value measured at the acute stage of ON was correlated with the thickness of the RNFL (<jats:italic>r<\/jats:italic>\u2009=\u20090.441; <jats:italic>P<\/jats:italic>\u2009=\u20090.006) and the GCC (<jats:italic>r<\/jats:italic>\u2009=\u20090.526; <jats:italic>P<\/jats:italic> &lt; 0.0001) after 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ADC value might be helpful for differentiating MS\u2010ON from NMO\u2010ON patients. The decreased ADC value was correlated with optic nerve atrophy on OCT.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 3<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. MAGN. 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IMAGING 2017;45:1780\u20131785<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25528","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T21:13:47Z","timestamp":1478726027000},"page":"1780-1785","source":"Crossref","is-referenced-by-count":20,"title":["Diffusion\u2010weighted imaging helps differentiate multiple sclerosis and neuromyelitis optica\u2010related acute optic neuritis"],"prefix":"10.1002","volume":"45","author":[{"given":"Hailin","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Radiology, Shanghai Pudong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Pudong Hospital Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye &amp; 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