{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:55:09Z","timestamp":1760014509607},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Addenbrooke's Charitable Trust"},{"name":"NIHR Cambridge Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the diagnostic performance of velocity\u2010 and acceleration\u2010sensitized noncontrast\u2010enhanced magnetic resonance angiography (NCE\u2010MRA) of the infrageniculate arteries using contrast\u2010enhanced MRA (CE\u2010MRA) as a reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010four patients with symptoms of peripheral arterial disease were recruited. Each patient's infrageniculate arterial tree was examined using a velocity\u2010dependent flow\u2010sensitized dephasing (VEL\u2010FSD) technique, an acceleration\u2010dependent (ACC\u2010FSD) technique, and our conventional CE\u2010MRA technique performed at 1.5T. The images were independently reviewed by two experienced vascular radiologists, who evaluated each vessel segment to assess visibility, diagnostic confidence, venous contamination, and detection of pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 432 segments were evaluated by each of the three techniques by each reader in total. Overall diagnostic confidence was rated as moderate or high in 98.5% of segments with CE\u2010MRA, 92.1% with VEL\u2010FSD, and 79.9% with ACC\u2010FSD. No venous contamination was seen in 96% of segments with CE\u2010MRA, 72.2% with VEL\u2010FSD, and 85.8% with ACC\u2010FSD. Per\u2010segment, per\u2010limb, and per\u2010patient sensitivities for detecting significant stenotic disease were 63.4%, 73%, and 92%, respectively, for ACC\u2010FSD, and 65.3%, 87.2%, and 96% for VEL\u2010FSD, and as such no significant statistical change was detected using McNemar's chi\u2010squared test with <jats:italic>P<\/jats:italic>\u2010values of 1.00, 0.13, and 0.77 obtained, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Flow\u2010dependent NCE\u2010MRA techniques may have a role to play in evaluation of patients with peripheral vascular disease. Increased sensitivity of a velocity\u2010based technique compared to an acceleration\u2010based technique comes at the expense of greater venous contamination.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2J.<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. MAGN. RESON. IMAGING 2017;45:1846\u20131853<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25533","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T19:38:50Z","timestamp":1480534730000},"page":"1846-1853","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of velocity\u2010sensitized and acceleration\u2010sensitized NCE\u2010MRA for below\u2010knee peripheral arterial disease"],"prefix":"10.1002","volume":"45","author":[{"given":"Nadeem","family":"Shaida","sequence":"first","affiliation":[{"name":"Department of Radiology Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew N.","family":"Priest","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.C.","family":"See","sequence":"additional","affiliation":[{"name":"Department of Radiology Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Winterbottom","sequence":"additional","affiliation":[{"name":"Department of Radiology Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Graves","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Lomas","sequence":"additional","affiliation":[{"name":"Academic Department of Radiology University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568006043336140"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/erc.10.134"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.2.170"},{"key":"e_1_2_6_5_1","first-page":"630","volume":"32","author":"Brockmann C","year":"2009","journal-title":"Dual energy CT angiography in peripheral arterial occlusive dsease CVIR"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2014.01.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/RLI.0000000000000273","article-title":"Safety of the gadolinium based contrast agents for MRI focusing in part on their accumulation in the brain and especially in the dentate nucleus","volume":"51","author":"Runge VM","year":"2016","journal-title":"Invest Radiol"},{"key":"e_1_2_6_8_1","first-page":"46","article-title":"MR angiography of peripheral arteries","volume":"87","author":"Ho KY","year":"2004","journal-title":"JBR\u2010BTR"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2273020227"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2363040865"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22567"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.12.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22287"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22142"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24124"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2132-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101336"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23040"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24626"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24981"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22149"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.07.057"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2008.12.006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.06.029"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21921"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24561"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.09.028"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1932-2"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24477"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2013.12.006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091078"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-012-0352-5"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25533","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:01:10Z","timestamp":1695574870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/jmri.25533"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25533","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}