{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:19:24Z","timestamp":1791209964260,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["U01 HD087211"],"award-info":[{"award-number":["U01 HD087211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","award":["R01 EB017337"],"award-info":[{"award-number":["R01 EB017337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Consejeria de Educacion, Juventud y Deporte de la Comunidad de Madrid (Spain) through the Madrid-MIT M+Vision Consortium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To present a method for spatiotemporal alignment of in\u2010utero magnetic resonance imaging (MRI) time series acquired during maternal hyperoxia for enabling improved quantitative tracking of blood oxygen level\u2010dependent (BOLD) signal changes that characterize oxygen transport through the placenta to fetal organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The proposed pipeline for spatiotemporal alignment of images acquired with a single\u2010shot gradient echo echo\u2010planar imaging includes 1) signal nonuniformity correction, 2) intravolume motion correction based on nonrigid registration, 3) correction of motion and nonrigid deformations across volumes, and 4) detection of the outlier volumes to be discarded from subsequent analysis. BOLD MRI time series collected from 10 pregnant women during 3T scans were analyzed using this pipeline. To assess pipeline performance, signal fluctuations between consecutive timepoints were examined. In addition, volume overlap and distance between manual region of interest (ROI) delineations in a subset of frames and the delineations obtained through propagation of the ROIs from the reference frame were used to quantify alignment accuracy. A previously demonstrated rigid registration approach was used for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proposed pipeline improved anatomical alignment of placenta and fetal organs over the state\u2010of\u2010the\u2010art rigid motion correction methods. In particular, unexpected temporal signal fluctuations during the first normoxia period were significantly decreased (<jats:italic>P<\/jats:italic> &lt; 0.01) and volume overlap and distance between region boundaries measures were significantly improved (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed approach to align MRI time series enables more accurate quantitative studies of placental function by improving spatiotemporal alignment across placenta and fetal organs.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 1<\/jats:p><jats:p>J. MAGN. RESON. IMAGING 2017;46:403\u2013412<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25585","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T15:52:00Z","timestamp":1486050720000},"page":"403-412","source":"Crossref","is-referenced-by-count":26,"title":["Spatiotemporal alignment of in utero BOLD\u2010MRI series"],"prefix":"10.1002","volume":"46","author":[{"given":"Esra Abaci","family":"Turk","sequence":"first","affiliation":[{"name":"Fetal\u2010Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"},{"name":"Madrid\u2010MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Luo","sequence":"additional","affiliation":[{"name":"Fetal\u2010Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"},{"name":"Madrid\u2010MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borjan","family":"Gagoski","sequence":"additional","affiliation":[{"name":"Department of Radiology Harvard Medical School, Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pascau","sequence":"additional","affiliation":[{"name":"Madrid\u2010MIT M+Vision Consortium in RLE, Massachusetts Institute of Technology Cambridge Massachusetts USA"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERSAM Madrid Spain"},{"name":"Departamento de Bioingenier\u00eda e Ingenier\u00eda Aeroespacial Universidad Carlos III de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Bibbo","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian N.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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