{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T12:55:27Z","timestamp":1755694527988,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7144231"],"award-info":[{"award-number":["7144231"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the severity of cerebral hemodynamic impairment and hemodynamic improvements, after revascularization in moyamoya disease (MMD) by means of blood\u2010oxygen\u2010level dependent functional magnetic resonance imaging (BOLD\u2010fMRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>BOLD\u2010fMRI with median nerve electrical stimulation based on echo planar imaging was performed in 73 volunteers with MMD and 15 healthy volunteers using a 3.0 Tesla MRI scanner. Twenty\u2010four MMD patients were reexamined after encephaloduroarteriosynangiosis. Time\u2010signal intensity curves of the activated area of the contralateral primary somatosensory cortex were computed. Negative response time (Tnr) and peak (Pnr), positive response time (Tpr) and peak (Ppr), and time to negative peak (TTPn) and positive peak (TTPp) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with nonparesthesia group and the asymptomatic side of paresthesia group, the patients with paresthesia showed extended Tnr (22.04\u2009\u00b1\u20093.34 s versus 9.57\u2009\u00b1\u20092.27 s and 12.67\u2009\u00b1\u20092.69 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0096), decreased Pnr (\u20130.47\u2009\u00b1\u20090.06 versus \u20130.30\u2009\u00b1\u20090.09 and \u20130.33\u2009\u00b1\u20090.09, <jats:italic>P<\/jats:italic>\u2009=\u20090.010), delayed TTPn (9.04\u2009\u00b1\u20091.39 s versus 3.66\u2009\u00b1\u20090.79 s and 4.88\u2009\u00b1\u20091.10 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0064), shortened Tpr (22.75\u2009\u00b1\u20092.30 s versus 36.85\u2009\u00b1\u20092.68 s and 33\u2009\u00b1\u20092.49 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0010), and decreased Ppr (0.62\u2009\u00b1\u20090.08 versus 0.99\u2009\u00b1\u20090.15 and 0.97\u2009\u00b1\u20090.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.0149) when subjected to median nerve electrical stimulation in the symptomatic side. After surgery, the patients with paresthesia showed shorter Tnr (1.53\u2009\u00b1\u20091.66 s versus 17.88\u2009\u00b1\u200922.61 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0002), increased Pnr (\u20130.14\u2009\u00b1\u20090.17 versus \u20130.44\u2009\u00b1\u20090.53, <jats:italic>P<\/jats:italic>\u2009=\u20090.0178), advanced TTPn (1.29\u2009\u00b1\u20091.21 s versus 7.29\u2009\u00b1\u20098.21 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0005), extended Tpr (36.94\u2009\u00b1\u20096.41 s versus 25.18\u2009\u00b1\u200915.51 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0091), increased Ppr (1.21\u2009\u00b1\u20090.87 versus 0.77\u2009\u00b1\u20090.60, <jats:italic>P<\/jats:italic>\u2009=\u20090.0201), and advanced TTPp (11.18\u2009\u00b1\u20094.70 s versus 27.29\u2009\u00b1\u200920.00 s, <jats:italic>P<\/jats:italic>\u2009=\u20090.0046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bold\u2010fMRI is useful to assess disease severity and surgical efficacy in MMD.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 4<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;46:1159\u20131166.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25598","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T15:59:30Z","timestamp":1486051170000},"page":"1159-1166","source":"Crossref","is-referenced-by-count":2,"title":["BOLD\u2010fMRI with median nerve electrical stimulation predict hemodynamic improvement after revascularization in patients with moyamoya disease"],"prefix":"10.1002","volume":"46","author":[{"given":"Peng\u2010Gang","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Radiology, Xijing Hospital The Fourth Military Medical University Xi'an China"},{"name":"Department of Radiology Affiliated Hospital of Academy of Military Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital of Academy of Military Medical Sciences Beijing 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