{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:09Z","timestamp":1786978089487,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\/NINDS 5R01NS078828"],"award-info":[{"award-number":["NIH\/NINDS 5R01NS078828"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\/NINDS 1R01NS097763"],"award-info":[{"award-number":["NIH\/NINDS 1R01NS097763"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare cerebrovascular reactivity (CVR) and CVR lagtimes in flow territories perfused by vessels with vs. without proximal arterial wall disease and\/or stenosis, separately in patients with atherosclerotic and nonatherosclerotic (moyamoya) intracranial stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Atherosclerotic and moyamoya patients with &gt;50% intracranial stenosis and &lt;70% cervical stenosis underwent angiography, vessel wall imaging (VWI), and CVR\u2010weighted imaging (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936; vessel segments evaluated\u2009=\u2009396). Angiography and VWI were evaluated for stenosis locations and vessel wall lesions. Maximum CVR and CVR lagtime were contrasted between vascular territories with and without proximal intracranial vessel wall lesions and stenosis, and a Wilcoxon rank\u2010sum was test used to determine differences (criteria: corrected two\u2010sided\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CVR lagtime was prolonged in territories with vs. without a proximal vessel wall lesion or stenosis for both patient groups: moyamoya (CVR lagtime\u2009=\u200945.5 sec\u2009\u00b1\u200914.2 sec vs. 35.7 sec\u2009\u00b1\u20099.7 sec,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and atherosclerosis (CVR lagtime\u2009=\u200938.2 sec\u2009\u00b1\u20099.1 sec vs. 35.0 sec\u2009\u00b1\u20097.2 sec,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). For reactivity, a significant decrease in maximum CVR in the moyamoya group only (maximum CVR\u2009=\u20099.8\u2009\u00b1\u20092.2 vs. 12.0\u2009\u00b1\u20092.4,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Arterial vessel wall lesions detected on noninvasive, noncontrast intracranial VWI in patients with intracranial stenosis correlate on average with tissue\u2010level impairment on CVR\u2010weighted imaging.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Level of Evidence:<\/jats:bold>\n                      4\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Technical Efficacy:<\/jats:bold>\n                      Stage 3\n                    <\/jats:p>\n                    <jats:p>J. Magn. Reson. Imaging 2017;46:1167\u20131176.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.25602","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T13:39:12Z","timestamp":1483709952000},"page":"1167-1176","source":"Crossref","is-referenced-by-count":12,"title":["Impact of vessel wall lesions and vascular stenoses on cerebrovascular reactivity in patients with intracranial stenotic disease"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8128-4476","authenticated-orcid":false,"given":"Petrice M.","family":"Cogswell","sequence":"first","affiliation":[{"name":"Department of Radiology Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Radiology Vanderbilt University Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan 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