{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:35:16Z","timestamp":1761863716413},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA133490","R01 CA167785"],"award-info":[{"award-number":["R01 CA133490","R01 CA167785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004888","name":"Illinois Department of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop and assess a full\u2010coverage, sensitivity encoding (SENSE)\u2010accelerated breast high spatial and spectral resolution (HiSS) magnetic resonance imaging (MRI) within clinically reasonable times as a potential nonenhanced MRI protocol for breast density measurement or breast cancer screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixteen women with biopsy\u2010proven cancer or suspicious lesions, and 13 women who were healthy volunteers or were screened for breast cancer, received 3T breast MRI exams, including SENSE\u2010accelerated HiSS MRI, which was implemented as a submillimeter spatial resolution echo\u2010planar spectroscopic imaging (EPSI) sequence. In postprocessing, fat and water resonance peak height and integral images were generated from EPSI data. The postprocessing software was custom\u2010designed, and new algorithms were developed to enable processing of whole\u2010coverage axial HiSS datasets. Water peak height HiSS images were compared to pre\u2010 and postcontrast <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted images. Fat suppression was quantified as parenchymal\u2010to\u2010suppressed\u2010fat signal ratio in HiSS water peak height and nonenhanced <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted images, and artifact levels were scored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately a 4\u2010fold decrease in acquisition speed, with a concurrent 2.5\u2010fold decrease in voxel size, was achieved, with low artifact levels, and with spectral signal\u2010to\u2010noise ratio (SNR) of 45:1. Fat suppression was 1.9 times more effective (<jats:italic>P<\/jats:italic> &lt; 0.001) in HiSS images than in <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted images (SPAIR), and HiSS images showed higher SNR in the axilla. HiSS MRI visualized 10 of 13 malignant lesions identified on dynamic contrast\u2010enhanced (DCE)\u2010MRI, and did not require skin removal in postprocessing to generate maximum intensity projection images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrate full\u2010coverage, SENSE\u2010accelerated breast HiSS MRI within clinically reasonable times, as a potential protocol for breast density measurement or breast cancer screening.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;46:1341\u20131348.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25658","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T15:12:55Z","timestamp":1488813175000},"page":"1341-1348","source":"Crossref","is-referenced-by-count":10,"title":["Fast bilateral breast coverage with high spectral and spatial resolution (HiSS) MRI at 3T"],"prefix":"10.1002","volume":"46","author":[{"given":"Milica","family":"Medved","sequence":"first","affiliation":[{"name":"Department of Radiology University of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Chicago Chicago Illinois 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