{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T15:56:18Z","timestamp":1781366178194,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["1R01NR015079"],"award-info":[{"award-number":["1R01NR015079"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To exploit the long 3.0T relaxation times and low flow velocity of lymphatic fluid to develop a noninvasive 3.0T lymphangiography sequence and evaluate its relevance in patients with lymphedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A 3.0T turbo\u2010spin\u2010echo (TSE) pulse train with long echo time (TE<jats:sub>effective<\/jats:sub>\u2009=\u2009600 msec; shot\u2010duration\u2009=\u200913.2 msec) and TSE\u2010factor (TSE\u2010factor\u2009=\u200990) was developed and signal evolution simulated. The method was evaluated in healthy adults (<jats:italic>n<\/jats:italic>\u2009=\u200911) and patients with unilateral breast cancer treatment\u2010related lymphedema (BCRL; <jats:italic>n<\/jats:italic>\u2009=\u200925), with a subgroup (<jats:italic>n<\/jats:italic>\u2009=\u20095) of BCRL participants scanned before and after manual lymphatic drainage (MLD) therapy. Maximal lymphatic vessel cross\u2010sectional area, signal\u2010to\u2010noise\u2010ratio (SNR), and results from a five\u2010point categorical scoring system were recorded. Nonparametric tests were applied to evaluate study parameter differences between controls and patients, as well as between affected and contralateral sides in patients (significance criteria: two\u2010sided <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient volunteers demonstrated larger lymphatic cross\u2010sectional areas in the affected (arm\u2009=\u200912.9\u2009\u00b1\u20096.3\u2009mm<jats:sup>2<\/jats:sup>; torso\u2009=\u200917.2\u2009\u00b1\u200915.6\u2009mm<jats:sup>2<\/jats:sup>) vs. contralateral (arm\u2009=\u20099.4\u2009\u00b1\u20093.9\u2009mm<jats:sup>2<\/jats:sup>; torso\u2009=\u20099.1\u2009\u00b1\u20094.6\u2009mm<jats:sup>2<\/jats:sup>) side; this difference was significant both for the arm (<jats:italic>P<\/jats:italic>\u2009=\u20090.014) and torso (<jats:italic>P<\/jats:italic>\u2009=\u20090.025). Affected (arm: <jats:italic>P<\/jats:italic>\u2009=\u20090.010; torso: <jats:italic>P<\/jats:italic>\u2009=\u20090.016) but not contralateral (arm: <jats:italic>P<\/jats:italic>\u2009=\u20090.42; torso: <jats:italic>P<\/jats:italic>\u2009=\u20090.71) vessel areas were significantly elevated compared with control values. Lymphatic cross\u2010sectional areas reduced following MLD on the affected side (pre\u2010MLD: arm\u2009=\u20098.8\u2009\u00b1\u20091.8\u2009mm<jats:sup>2<\/jats:sup>; torso\u2009=\u200931.4\u2009\u00b1\u200926.0\u2009mm<jats:sup>2<\/jats:sup>; post\u2010MLD: arm\u2009=\u20096.6\u2009\u00b1\u20091.8\u2009mm<jats:sup>2<\/jats:sup>; torso\u2009=\u200923.1\u2009\u00b1\u200924.3\u2009mm<jats:sup>2<\/jats:sup>). This change was significant in the torso (<jats:italic>P<\/jats:italic>\u2009=\u20090.036). The categorical scoring was found to be less specific for detecting lateralizing disease compared to lymphatic\u2010vessel areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 3.0T lymphangiography sequence is proposed, which allows for upper extremity lymph stasis to be detected in \u223c10 minutes without exogenous contrast agents.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017;46:1349\u20131360.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25670","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T16:17:59Z","timestamp":1488298679000},"page":"1349-1360","source":"Crossref","is-referenced-by-count":33,"title":["Lymphedema evaluation using noninvasive 3T MR lymphangiography"],"prefix":"10.1002","volume":"46","author":[{"given":"Rachelle","family":"Crescenzi","sequence":"first","affiliation":[{"name":"Radiology and Radiological Science Vanderbilt University School of Medicine Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-6539","authenticated-orcid":false,"given":"Paula M.C.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Vanderbilt University School of Medicine Nashville Tennessee USA"},{"name":"Dayani Center for Health and Wellness Vanderbilt University School of Medicine 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