{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:52:40Z","timestamp":1773683560974,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the use of functional magnetic resonance imaging (MRI), including diffusion\u2010weighted MRI (DWI) and magnetization transfer MRI (MTI) in evaluating male infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixteen men with testicular spermatogenesis hypofunction confirmed by percutaneous testis biopsy and 31 volunteers (control group B, age range: 20\u201340 years) with normal semen analysis including younger (By, <jats:italic>n<\/jats:italic> = 15, age range: 20\u201330 years) and older (Bo, <jats:italic>n<\/jats:italic> = 16, age range: 31\u201340 years) men underwent pelvic 3T MRI, including DWI and MTI. Apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ADCs in 32 testes of 16 patients (0.497 \u00b1 0.037 \u00d7 10<jats:sup>\u20103<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s) were significantly (<jats:italic>P<\/jats:italic> &lt; 0.001) higher than that of control group B (0.460 \u00b1 0.031 \u00d7 10<jats:sup>\u20103<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s), group By (0.453 \u00b1 0.018 \u00d7 10<jats:sup>\u20103<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s), and group Bo (0.461 \u00b1 0.034 \u00d7 10<jats:sup>\u20103<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s), whereas the MTRs were significantly lower than that of group B (16.14 \u00b1 4.20), group By (17.88 \u00b1 2.00), and group Bo (15.09 \u00b1 4.28) (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Functional MRI, including DWI and MTI, appears promising for evaluating male infertility with higher ADC and lower MTR in testicular spermatogenesis hypofunction.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:186\u2013190.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25732","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T16:12:25Z","timestamp":1492099945000},"page":"186-190","source":"Crossref","is-referenced-by-count":23,"title":["Diffusion\u2010Weighted and Magnetization Transfer Imaging in Testicular Spermatogenic Function Evaluation: Preliminary Results"],"prefix":"10.1002","volume":"47","author":[{"given":"Huanjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Lin","sequence":"additional","affiliation":[{"name":"Ultrosounic Department First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Cancer Biology, Radiology Wake Forest School of Medicine Winston\u2010Salam North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shurong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huasong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0032-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/31818161"},{"issue":"6","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.2214\/AJR.07.7109","article-title":"Imaging of male infertility: pictorial review","volume":"192","author":"Simpson WL","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2014.01.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.254"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1403"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10404"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910100113"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.14.2.8190954"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.122865"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3867-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2012.08.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.1.3547497"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000281524","article-title":"The value of magnetic resonance imaging at 1.5 T in the evaluation of the scrotal content","volume":"44","author":"Sohn M","year":"1989","journal-title":"Urol Int"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11619"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(99)00075-4"},{"key":"e_1_2_7_18_1","first-page":"140","article-title":"Effect of aging on the volume, structure and total Leydig cell content of the human testis","volume":"19","author":"Kothari LK","year":"1974","journal-title":"Int J Fertil"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0700211"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2674"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:57:34Z","timestamp":1695887854000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jmri.25732"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25732","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}