{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:38:09Z","timestamp":1780069089576,"version":"3.54.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Natural Science Foundation for Young Scholars of China","award":["81501440"],"award-info":[{"award-number":["81501440"]}]},{"name":"Project of Shanghai Municipal Science and Technology Commission","award":["16ZR1404600"],"award-info":[{"award-number":["16ZR1404600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To quantitatively evaluate the cartilage alteration of talus for chronic lateral ankle instability (LAI) with isolated anterior talofibular ligament (ATFL) tear and combined ATFL and calcaneofibular ligament (CFL) tear using <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010mapping at 3.0T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In all, 27 patients including 17 with isolated ATFL tear and 10 with ATFL+CFL tear, and 21 healthy subjects were recruited. All participants underwent <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010mapping scan at 3T and patients completed American Orthopaedic Foot and Ankle Society (AOFAS) scoring. The total talar cartilage (TTC) was segmented into six compartments: medial anterior (MA), medial center (MC), medial posterior (MP), lateral anterior (LA), lateral center (LC), and lateral posterior (LP). The <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> value of each compartment was measured from <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010mapping images. Data were analyzed with one\u2010way analysis of variance (ANOVA), Student's <jats:italic>t<\/jats:italic>\u2010test, and Pearson's correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values of MA, MC, MP, TTC in the ATFL group and MA, MC, MP, LC, LP, TTC in the ATFL+CFL group were higher than those in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values of MC, MP, LC, and TTC in the ATFL+CFL group were higher than those in the ATFL group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values of MA in both patient groups were negatively correlated with AOFAS scores (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.596, <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.690, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic LAI with ATFL tear had a trend of increasing cartilage <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values in talar trochlea, mainly involving medial cartilage compartments. Chronic LAI with ATFL+CFL tear might result in higher <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub> values in a much larger cartilage region than with ATFL tear. MA could be the main cartilage compartment that may affect the patient's clinical symptoms.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:69\u201377.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25745","type":"journal-article","created":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T21:03:31Z","timestamp":1493327011000},"page":"69-77","source":"Crossref","is-referenced-by-count":35,"title":["<i>T<\/i><sub>2<\/sub>\u2010Mapping evaluation of early cartilage alteration of talus for chronic lateral ankle instability with isolated anterior talofibular ligament tear or combined with calcaneofibular ligament tear"],"prefix":"10.1002","volume":"47","author":[{"given":"Hongyue","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Radiology, Huashan Hospital Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hospital Fudan University Shanghai P.R. 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