{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:36:49Z","timestamp":1756384609533,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81401389","81501546"],"award-info":[{"award-number":["NSFC 81401389","81501546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the region\u2010specific atrophy of precentral gyrus (PrCG) and its correlation to clinical function score in amyotrophic lateral sclerosis (ALS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010eight patients with sporadic ALS and 28 healthy controls underwent high\u2010resolution 3D T1\u2010BRAVO magnetic resonance imaging at 3T. The bilateral PrCG segmentations were automatically obtained from a validated segmentation pipeline based on diffeomorphic multi\u2010atlas likelihood fusion. Patients with ALS were further subclassified into early\u2010stage (ALS\u2010e, <jats:italic>n<\/jats:italic>\u2009=\u200922) and late\u2010stage (ALS\u2010l, <jats:italic>n<\/jats:italic>\u2009=\u20096) groups, with 12 months as a disease duration cutoff. Vertex\u2010based shape analysis was performed to quantify the region\u2010specific abnormalities of PrCG in ALS subgroups as compared to controls. In addition, we tested the statistical association between altered PrCG morphometry and clinical disability in ALS as evaluated by the revised ALS Functional Rating Scale (ALSFRS\u2010r).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, vertex\u2010wise analysis showed that both ALS\u2010e and ALS\u2010l had significant atrophy of the dorsal\u2010lateral part of PrCG (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, uncorrected). Importantly, atrophy in ALS\u2010e was not as widespread as that in ALS\u2010l; while atrophy in ALS\u2010e was mostly confined to the dorsal\u2010lateral region (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, uncorrected, surface areas exhibiting significant difference at a level of <jats:italic>P<\/jats:italic>\u2009=\u20090.05: left 613.88\u2009mm<jats:sup>2<\/jats:sup>, right 937.80\u2009mm<jats:sup>2<\/jats:sup>), atrophy in ALS\u2010l occurred at the dorsal\u2010medial and ventral region as well (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, uncorrected, surface areas exhibiting significant difference at a level of <jats:italic>P<\/jats:italic>\u2009=\u20090.05: left 1465.98\u2009mm<jats:sup>2<\/jats:sup>, right 1253.89\u2009mm<jats:sup>2<\/jats:sup>). Partial correlation analysis showed that the significant surface area atrophy of PrCG in ALS, especially that of the dorsal\u2010lateral portion, was found to link tightly with ALSFRS\u2010r (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, uncorrected, surface areas exhibiting significant correlation: left 723.08\u2009mm<jats:sup>2<\/jats:sup>, right 474.24\u2009mm<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that an altered PrCG morphometry, especially atrophy of the surface area in the dorsal\u2010lateral portion, may be associated with the dysfunction that characterizes ALS. This study is an initial attempt to apply a validated statistical shape analysis pipeline to cortical gray matter structure like PrCG.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy Stage:<\/jats:bold> 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:115\u2013122.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25765","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T20:12:38Z","timestamp":1496866358000},"page":"115-122","source":"Crossref","is-referenced-by-count":7,"title":["Region\u2010specific atrophy of precentral gyrus in patients with amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-3200","authenticated-orcid":false,"given":"Yuanyuan","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiehe Hospital, Fujian Medical University Fuzhou Fujian P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"Shandong Medical Imaging Research Institute Shandong University Jinan P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Tang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Carnegie Mellon University (SYSU\u2010CMU) Joint Institute of Engineering Sun Yat\u2010sen University Guangzhou Guangdong P.R. China"},{"name":"SYSU\u2010CMU Shunde International Joint Research Institute Shunde Guangdong P.R. China"},{"name":"School of Electronics and Information Technology Sun Yat\u2010sen University Guangzhou Guangdong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2010000600002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820410021311"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600947648"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03161081"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0685-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2012000700012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00104-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4562"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00304-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1998.00108.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-300909"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302674"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820510038538"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.9.1571"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0646-x"},{"key":"e_1_2_7_17_1","first-page":"255","article-title":"Whole\u2010brain and regional brain atrophy in amyotrophic lateral sclerosis","volume":"28","author":"Mezzapesa DM","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042816"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20364"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.046"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194316.91908.8a"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065591"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00061"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.042"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(87)90124-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22758"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22431"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/11505730_32"},{"key":"e_1_2_7_32_1","first-page":"1524","article-title":"Reproducibility of primary motor cortex somatotopy under controlled conditions","volume":"23","author":"Alkadhi H","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/NRE-2007-22602","article-title":"Clinical presentation and diagnosis of amyotrophic lateral sclerosis","volume":"22","author":"Ferguson TA","year":"2007","journal-title":"NeuroRehabilitation"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119045"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b6bbbd"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802267530"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828869da"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22188"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080748"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141605"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22214"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:56:31Z","timestamp":1695887791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1002\/jmri.25765"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25765","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"type":"print","value":"1053-1807"},{"type":"electronic","value":"1522-2586"}],"subject":[],"published":{"date-parts":[[2017,6,7]]}}}