{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T13:36:05Z","timestamp":1771076165241,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010AR\u20102\u20102258; N01\u2010AR\u20102\u20102259; N01\u2010AR\u20102\u20102260; N01\u2010AR\u20102\u20102261; N01\u2010AR\u20102\u20102262"],"award-info":[{"award-number":["N01\u2010AR\u20102\u20102258; N01\u2010AR\u20102\u20102259; N01\u2010AR\u20102\u20102260; N01\u2010AR\u20102\u20102261; N01\u2010AR\u20102\u20102262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P50AR060752"],"award-info":[{"award-number":["P50AR060752"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR064771"],"award-info":[{"award-number":["R01AR064771"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the association of the presence and severity of diabetes mellitus (DM) with articular cartilage composition, using magnetic resonance imaging (MRI)\u2010based T<jats:sub>2<\/jats:sub> relaxation time measurements, and structural knee abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the Osteoarthritis Initiative 208, participants with DM (age 63.0 \u00b1 8.9 years; 111 females) and risk factors for osteoarthritis (OA) or mild radiographic tibiofemoral OA (Kellgren\u2013Lawrence [KL] grade \u22642) were identified and group\u2010matched with 208 controls without DM (age 63.3 \u00b1 9.1 years; 111 females). Subjects with diabetes\u2010related renal or ophthalmological complications or insulin treatment at baseline (<jats:italic>n<\/jats:italic> = 50) were defined as severe DM. 3T MR images of the right knee were assessed for articular cartilage T<jats:sub>2<\/jats:sub>, including texture and laminar analyses derived from the patella, medial, and lateral femur and tibia and for structural abnormalities using the modified whole\u2010organ magnetic resonance imaging score (WORMS). Clustered linear regression analyses were used to assess associations of DM with MRI findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DM subjects had significantly higher cartilage T<jats:sub>2<\/jats:sub> in the patella (mean difference 0.92 msec [95% confidence interval (CI) 0.79, 1.06]; <jats:italic>P<\/jats:italic> = 0.001) and medial femur (mean difference 0.36 msec [95% CI 0.27, 0.81]; <jats:italic>P<\/jats:italic> = 0.006) compared to controls. Averaged over all compartments, DM subjects showed significantly higher texture parameters (variance, <jats:italic>P<\/jats:italic> = 0.001; contrast, <jats:italic>P<\/jats:italic> = 0.002; entropy, <jats:italic>P<\/jats:italic> &lt; 0.001). Subjects with severe DM additionally showed higher T<jats:sub>2<\/jats:sub> in the medial tibial deep and superficial layers (<jats:italic>P<\/jats:italic> = 0.011 and <jats:italic>P<\/jats:italic> = 0.041) compared to controls. No significant differences in cartilage, meniscus, and overall WORMS were found between the groups (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In comparison to nondiabetic controls, cartilage in DM subjects showed higher and more heterogeneous cartilage T<jats:sub>2<\/jats:sub> values, indicating increased articular cartilage degeneration. This affected even more compartments in subjects with severe DM.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> 5<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:380\u2013390.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25766","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T02:06:53Z","timestamp":1495850813000},"page":"380-390","source":"Crossref","is-referenced-by-count":29,"title":["Association of diabetes mellitus and biochemical knee cartilage composition assessed by T<sub>2<\/sub> relaxation time measurements: Data from the osteoarthritis initiative"],"prefix":"10.1002","volume":"47","author":[{"given":"Nattagan","family":"Chanchek","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco California USA"},{"name":"Department of Radiology, Faculty of Medicine Naresuan University Phitsanulok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra S.","family":"Gersing","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California 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B.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine UC Davis Medical Center Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Zarnowski","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix C.","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California San Francisco California 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