{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:34:54Z","timestamp":1765438494185,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the ability of high field ex vivo magnetic resonance imaging (MRI) to localize prostate cancer (PCa) and to predict the margin status in fresh radical prostatectomy (RP) specimens using histology as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This Institutional Review Board (IRB)\u2010approved study had written informed consent. Patients with biopsy\u2010proved PCa and a diagnostic multiparametric 3T MRI examination of the prostate prior to undergoing RP were prospectively included. A custom\u2010made container provided reference between the 7T ex vivo MRI obtained from fresh RP specimens and histological slicing. On ex vivo MRI, PCa was localized and the presence of positive surgical margins was determined in a double\u2010reading session. These findings were compared with histological findings obtained from completely cut, whole\u2010mount embedded, prostate specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 12 RP specimens, histopathology revealed 36 PCa lesions, of which 17 (47%) and 20 (56%) were correlated with the ex vivo MRI in the first and second reading session, respectively. Nine of 12 (75%) index lesions were localized in the first session, in the second 10 of 12 (83%). Seven and 8 lesions of 11 lesions with Gleason score &gt;6 and &gt;0.5 cc were localized in the first and second session, respectively. In the first session none of the four histologically positive surgical margins (sensitivity 0%) and 9 of 13 negative margins (specificity 69%) were detected. In second session the sensitivity and specificity were 25% and 88%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ex vivo MRI enabled accurate localization of PCa in fresh RP specimens, and the technique provided information on the margin status with high specificity.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 1<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:439\u2013448.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25785","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T05:06:41Z","timestamp":1496639201000},"page":"439-448","source":"Crossref","is-referenced-by-count":10,"title":["Ex vivo MRI evaluation of prostate cancer: Localization and margin status prediction of prostate cancer in fresh radical prostatectomy specimens"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-1486","authenticated-orcid":false,"given":"Jan","family":"Heidkamp","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Hoogenboom","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iringo E.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andor","family":"Veltien","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Maat","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P. Michiel","family":"Sedelaar","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina A.","family":"Hulsbergen\u2010van de Kaa","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgen J.","family":"F\u00fctterer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Radboud University Medical Center Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.07.033"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/03008880510030932","article-title":"Prognostic factors and reporting of prostate carcinoma in radical prostatectomy and pelvic lymphadenectomy specimens","volume":"39","author":"Epstein JI","year":"2005","journal-title":"Scand J Urol Nephrol Suppl"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.09.051"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.07.039"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.047"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0360-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2377-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.156"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.12.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23767"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23614"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2013.2269174"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22745"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13523"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12637"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13234"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12189"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13285"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.057"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00345-015-1623-3","article-title":"Intraoperative frozen section monitoring during nerve\u2010sparing radical prostatectomy: evaluation of partial secondary resection of neurovascular bundles and its effect on oncologic and functional outcome","volume":"34","author":"Hatzichristodoulou G","year":"2015","journal-title":"World J Urol"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T16:50:25Z","timestamp":1695919825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jmri.25785"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25785","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"type":"print","value":"1053-1807"},{"type":"electronic","value":"1522-2586"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}