{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:53:34Z","timestamp":1788368014877,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant of Science and Technology Commission of Shanghai Municipality","award":["17411962100"],"award-info":[{"award-number":["17411962100"]}]},{"name":"Grant of Science and Technology Commission of Shanghai Municipality","award":["14411962000"],"award-info":[{"award-number":["14411962000"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["ZK2015A05"],"award-info":[{"award-number":["ZK2015A05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the use of magnetic resonance (MR) diffusion kurtosis imaging (DKI) and dynamic contrast\u2010enhanced MR imaging (DCE\u2010MRI) in the differentiation of olfactory neuroblastomas (ONBs) from squamous cell carcinomas (SCCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>DKI and DCE\u2010MRI were performed in 17 patients with ONBs and 23 patients with SCCs on a 3T MR scanner. Parameters derived from DKI and DCE\u2010MRI were measured and compared between ONBs and SCCs using an independent samples<jats:italic>t<\/jats:italic>\u2010test. The sensitivity, specificity, accuracy, positive predictive values (PPV), negative predictive values (NPV), and the area under the receiver operating characteristic (ROC) curve were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean kurtosis (K) value of ONBs was significantly higher than that of SCCs (<jats:italic>P<\/jats:italic>&lt; 0.001), and the mean fractional volume in the extravascular extracellular space (V<jats:sub>e<\/jats:sub>) value of ONBs was lower than that of SCCs (<jats:italic>P<\/jats:italic>&lt; 0.001). The ROC curve analyses yielded a cutoff K value of 0.953, with a sensitivity of 94.1%, a specificity of 69.6%, and an accuracy of 80.0%; the cutoff V<jats:sub>e<\/jats:sub>value was 0.493, with a sensitivity of 70.6%, a specificity of 95.7%, and an accuracy of 85.0%. A parallel test with K value &gt;0.953 or V<jats:sub>e<\/jats:sub>value \u22640.493 achieved a sensitivity of 94.1%, a specificity of 100.0%, and an accuracy of 97.5% for differentiating ONBs from SCCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The K value of DKI and V<jats:sub>e<\/jats:sub>value of DCE\u2010MRI have potential use in the differentiation of ONBs and SCCs.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold>3<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold>Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:354\u2013361.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25803","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T13:28:33Z","timestamp":1498742913000},"page":"354-361","source":"Crossref","is-referenced-by-count":19,"title":["Differentiation of olfactory neuroblastomas from nasal squamous cell carcinomas using MR diffusion kurtosis imaging and dynamic contrast\u2010enhanced MRI"],"prefix":"10.1002","volume":"47","author":[{"given":"Zebin","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Radiology Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-5905","authenticated-orcid":false,"given":"Zuohua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai P.R. 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