{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:02:24Z","timestamp":1773097344537,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Premature ejaculation (PE) is one of the most common sexual dysfunctions in men. However, there has been little research evaluating alterations in brain structure related to PE. We aimed to investigate the characteristics of nonmedicated PE patients in terms of brain morphometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The sample consisted with 32 medication\u2010na\u00efve adult men with clinical diagnosed PE and matched 31 healthy controls. All participants received diagnostic interviews and 3.0 Tesla MRI scans. Automatic segmentation processing of MRI structure images was performed using FreeSurfer software and cerebral cortical thickness between groups was compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PE group had thicker cortex in widespread regions, including the frontal, parietal and occipital lobe, and limbic system, compared with the healthy control group (<jats:italic>P<\/jats:italic> &lt; 0.05). Moreover, the duration is negatively correlated with the mean cortical thickness of the right medial orbitofrontal cortex, right precentral gyrus and left superior frontal cortex (R<jats:sup>2<\/jats:sup> = 0.29, <jats:italic>P<\/jats:italic> &lt; 0.003; R<jats:sup>2<\/jats:sup> = 0.163, <jats:italic>P<\/jats:italic> &lt; 0.04; R<jats:sup>2<\/jats:sup> = 0.2, <jats:italic>P<\/jats:italic> &lt; 0.02), while the Premature Ejaculation Diagnostic Tool score is negatively correlated with the mean cortical thickness of the left caudal middle frontal cortex (R<jats:sup>2<\/jats:sup> = 0.33, <jats:italic>P<\/jats:italic> &lt; 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The result highlights the structural features of PE and suggests the relationship with the severity of impairment is related to the severity of anatomic abnormality with the relevant brain region. These results support the value of imaging measures as markers for understanding the physiopathology of PE.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:656\u2013662.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25808","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T06:58:36Z","timestamp":1500879516000},"page":"656-662","source":"Crossref","is-referenced-by-count":30,"title":["Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study"],"prefix":"10.1002","volume":"47","author":[{"given":"Fan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Radiology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"},{"name":"Key Laboratory of Molecular Imaging of the Chinese Academy of Sciences Institute of Automation, Chinese Academy of Sciences Beijing P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Bin","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Radiology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"},{"name":"Assisted Reproduction Center Northwest Women and Children Hospital\/Maternity Hospital of Shaanxi Province Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center School of Life Sciences and Technology, Xidian University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning\u2010Bo","family":"Fei","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center School of Life Sciences and Technology, Xidian University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[{"name":"Life Sciences Research Center School of Life Sciences and Technology, Xidian University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long\u2010Biao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Radiology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Urology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Urology Xijing Hospital, The Fourth Military Medical University Xi'an Shaanxi P.R. 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