{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:55:45Z","timestamp":1778817345806,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R01HL129185"],"award-info":[{"award-number":["1R01HL129185"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R21HL127650"],"award-info":[{"award-number":["1R21HL127650"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","award":["15EIA22710040"],"award-info":[{"award-number":["15EIA22710040"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study the relationship between diffuse myocardial fibrosis and complex ventricular arrhythmias (ComVA) in patients with nonischemic dilated cardiomyopathy (NICM). We hypothesized that NICM patients with ComVA would have a higher native myocardial T<jats:sub>1<\/jats:sub> time, suggesting more extensive myocardial diffuse fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We prospectively enrolled NICM patients with a history of ComVA (<jats:italic>n<\/jats:italic> = 50) and age\u2010matched NICM patients without ComVA (<jats:italic>n<\/jats:italic> = 57). Imaging was performed at 1.5T with a protocol that included cine magnetic resonance imaging (MRI) for left ventricular (LV) function, late gadolinium enhancement (LGE) for focal scar, and native T<jats:sub>1<\/jats:sub> mapping for diffuse fibrosis assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global native T<jats:sub>1<\/jats:sub> time was significantly higher in patients with NICM with ComVA when compared to patients with NICM without ComVA (1131 \u00b1 42 vs. 1107 \u00b1 45 msec, <jats:italic>P<\/jats:italic> = 0.006), and this finding remained after excluding segments with scar on LGE (1124 \u00b1 36 vs. 1102 \u00b1 44 msec, <jats:italic>P<\/jats:italic> = 0.006). Native T<jats:sub>1<\/jats:sub> was similar in NICM patients with and without the presence of LGE (1121 \u00b1 39 vs. 1117 \u00b1 48 msec, <jats:italic>P<\/jats:italic> = 0.68) and mildly correlated with LV end\u2010diastolic volume index (<jats:italic>r<\/jats:italic> = 0.27, <jats:italic>P<\/jats:italic> = 0.005), LV end\u2010systolic volume index (<jats:italic>r<\/jats:italic> = 0.24, <jats:italic>P<\/jats:italic> = 0.01), and LV ejection fraction (<jats:italic>r<\/jats:italic> = \u20130.28, <jats:italic>P<\/jats:italic> = 0.003). Native T<jats:sub>1<\/jats:sub> value for each 10\u2010msec increment was an independent predictor of ComVA (odds ratio 1.14, 95% confidence interval 1.03\u20131.25; <jats:italic>P<\/jats:italic> = 0.008) beyond LV function and LGE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NICM patients with ComVA have higher native T<jats:sub>1<\/jats:sub> compared to NICM without any documented ComVA. Native myocardial T<jats:sub>1<\/jats:sub> is independently associated with ComVA, after adjusting for LV function and LGE.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 2<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:779\u2013786.<\/jats:p><jats:p><jats:bold>In memoriam:<\/jats:bold> The authors are grateful for Dr. Josephson's inspiring guidance and contributions to this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25811","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T07:05:11Z","timestamp":1500879911000},"page":"779-786","source":"Crossref","is-referenced-by-count":41,"title":["Increased myocardial native T<sub>1<\/sub> relaxation time in patients with nonischemic dilated cardiomyopathy with complex ventricular arrhythmia"],"prefix":"10.1002","volume":"47","author":[{"given":"Shiro","family":"Nakamori","sequence":"first","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An H.","family":"Bui","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"},{"name":"Harvard\u2010Thorndike Electrophysiology Institute Cardiovascular Division, Department of Medicine, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihye","family":"Jang","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam A.","family":"El\u2010Rewaidy","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Kato","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long H.","family":"Ngo","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"},{"name":"Harvard\u2010Thorndike Electrophysiology Institute Cardiovascular Division, Department of Medicine, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren J.","family":"Manning","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Radiology Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Nezafat","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62023-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004133421502"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033088"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.049"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.018"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.05.013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb06199.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01736.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000078641.19365.4C"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi258"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.08.019"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"pii","DOI":"10.1161\/CIRCIMAGING.115.003285","article-title":"T1 mapping in discrimination of hypertrophic phenotypes: hypertensive heart disease and hypertrophic cardiomyopathy: Findings from the International T1 Multicenter Cardiovascular Magnetic Resonance Study","volume":"8","author":"Hinojar R","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303052"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14141120"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.10.046"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03928"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.12.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.12.020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.1.130"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25387"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12112489"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22841"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25270"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.5.686"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.4.847"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.3.589"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.4.1647"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.01.029"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1998.tb00907.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.041"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.500"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140296"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25255"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.005"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.968024"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.968057"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12456"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.09.012"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmri.25811","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.25811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T16:20:04Z","timestamp":1695658804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.25811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/jmri.25811"],"URL":"https:\/\/doi.org\/10.1002\/jmri.25811","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]}}}