{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:18:04Z","timestamp":1789931884019,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure without a clear cause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate dynamic imaging findings in IIH and their relation to mechanisms underlying intracranial pressure normalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population<\/jats:title><jats:p>Eighteen IIH patients and 30 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>T<jats:sub>1<\/jats:sub>\u2010weighted, venography, fluid attenuation inversion recovery, and apparent diffusion coefficients were acquired on 1.5T scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>The dural sinus was measured before and after lumbar puncture (LP). The degree of sinus occlusion was evaluated, based on 95% confidence intervals of controls. We studied a number of neuroimaging biomarkers associated with IIH (sinus occlusion; optic nerve; distribution of cerebrospinal fluid into the subarachnoid space, sulci and lateral ventricles (LVs); Meckel's caves; arachnoid granulation; pituitary and choroid plexus), before and after LP, using a set of specially developed quantification techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Relationships among various biomarkers were investigated (Pearson correlation coefficient) and linked to long\u2010term disease outcomes (logistic regression). The <jats:italic>t<\/jats:italic>\u2010test and the Wilcoxon rank test were used to compare between controls and before and after LP data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a result of LP, the following were found to be in good accordance with the opening pressure: relative compression of cerebrospinal fluid (R\u2009=\u2009\u20130.857, <jats:italic>P<\/jats:italic> &lt; 0.001) and brain volumes (R\u2009=\u2009\u20130.576, <jats:italic>P<\/jats:italic>\u2009=\u20090.012), LV expansion (R\u2009=\u20090.772, <jats:italic>P<\/jats:italic> &lt; 0.001) and venous volume (R\u2009=\u20090.696, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), enlargement of the pituitary (R\u2009=\u20090.640, <jats:italic>P<\/jats:italic>\u2009=\u20090.023), and shrinkage of subarachnoid space (R\u2009=\u2009\u20130.887, <jats:italic>P<\/jats:italic> &lt; 0.001). The only parameter that had an impact on long\u2010term prognosis was cross\u2010sectional size of supplemental drainage veins after LP (sensitivity of 92%, specificity of 20%, and area under the curve of 0.845, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>We present an approach for quantitative characterization of the intracranial venous system and its implementation as a diagnostic assistance tool. We conclude that formation of supplementary drainage veins might serve as a long\u2010lasting compensatory mechanism.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 2<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 3<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:913\u2013927.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25857","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:43:05Z","timestamp":1506613385000},"page":"913-927","source":"Crossref","is-referenced-by-count":18,"title":["Quantifying response to intracranial pressure normalization in idiopathic intracranial hypertension via dynamic neuroimaging"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-4887","authenticated-orcid":false,"given":"Svetlana","family":"Lublinsky","sequence":"first","affiliation":[{"name":"Departments of Brain &amp; Cognitive Sciences, Physiology &amp; Cell Biology, Faculty of Health Science, Zlotowski Center for Neuroscience Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Kesler","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University 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