{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:27:03Z","timestamp":1780068423916,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21 NS098018"],"award-info":[{"award-number":["R21 NS098018"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K08 HD073315"],"award-info":[{"award-number":["K08 HD073315"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD074593"],"award-info":[{"award-number":["R01 HD074593"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic resonance imaging (MRI) provides useful markers to examine placental function. MRI features of placental injury due to intrauterine inflammation\u2014a common risk during pregnancy, are not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the capability of structural MRI and intravoxel incoherent motion (IVIM) imaging in examining acute placental injury in a mouse model of intrauterine inflammation, as well as gestation\u2010dependent placental changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal Model<\/jats:title><jats:p>Pregnant CD1 mice were scanned on embryonic day 15 (E15, <jats:italic>n<\/jats:italic>\u2009=\u200940 placentas from six dams) and E17. On E17, mice were subjected to intrauterine injury by exposure to lipopolysaccharide (LPS, <jats:italic>n<\/jats:italic>\u2009=\u200925 placentas from three dams) or sham injury (<jats:italic>n<\/jats:italic>\u2009=\u200925 placentas from three dams).<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>In vivo MRI was performed on an 11.7T Bruker scanner, using a fast spin\u2010echo sequence and a diffusion\u2010weighted echo\u2010planar imaging (EPI) sequence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>T<jats:sub>2<\/jats:sub>\u2010weighted MRI was acquired to evaluate placental volume. IVIM imaging was performed in a restricted field\u2010of\u2010view using 15 b\u2010values from 10\u2013800 s\/mm<jats:sup>2<\/jats:sup>, based on which, the pseudodiffusion fraction (<jats:italic>f<\/jats:italic>), pseudodiffusion coefficient (<jats:italic>D<\/jats:italic>*), and tissue water coefficient (<jats:italic>D<\/jats:italic>) were estimated with a two\u2010step fitting procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Two\u2010way analysis of variance (ANOVA) was used to evaluate the group differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The placental volume increased by \u223c21% from E15 to E17 (<jats:italic>P<\/jats:italic> &lt; 0.01), and a 15% volume loss was observed at 6 hours after LPS exposure (<jats:italic>P<\/jats:italic> &lt; 0.01). IVIM parameters (<jats:italic>f, D<\/jats:italic>*, and <jats:italic>f<\/jats:italic>\u00b7<jats:italic>D<\/jats:italic>*) were similar between the E15 and E17 sham groups (<jats:italic>P<\/jats:italic> &gt; 0.05), which was significantly reduced in the LPS\u2010exposed placentas compared to the shams (<jats:italic>P<\/jats:italic> &lt; 0.001). <jats:italic>D<\/jats:italic> values decreased from E15 to E17 (<jats:italic>P<\/jats:italic> &lt; 0.05), which were further reduced after LPS exposure (<jats:italic>P<\/jats:italic> &lt; 0.05). Changes in placental area and vascular density were histologically identified in the LPS\u2010exposed group, along with gestation\u2010dependent changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>Our results suggested structural MRI and IVIM measurements are potential markers for detecting acute placental injury after intrauterine inflammation.<\/jats:p><jats:p><jats:bold>Level of Evidence<\/jats:bold>: 1<\/jats:p><jats:p><jats:bold>Technical Efficacy<\/jats:bold>: Stage 2<\/jats:p><jats:p>J. Magn. Reson. Imaging 2018;47:1260\u20131267.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25867","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T14:22:41Z","timestamp":1507213361000},"page":"1260-1267","source":"Crossref","is-referenced-by-count":14,"title":["In vivo assessment of the placental anatomy and perfusion in a mouse model of intrauterine inflammation"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-5821","authenticated-orcid":false,"given":"Dan","family":"Wu","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Gynecology and Obstetrics, Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Center for Prenatal and Hereditary Disease Diagnosis, Department of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"Department of Gynecology and Obstetrics, Xinqiao Hospital Third Military Medical University Chongqing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadi","family":"Xu","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Mori","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"},{"name":"F.M. 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