{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:13:50Z","timestamp":1783775630880,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transcranial MR\u2010guided high\u2010intensity focused ultrasound (tcMRgFUS) is a promising noninvasive method to treat medication\u2010refractory essential tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose\/Hypothesis<\/jats:title><jats:p>To define the correlation between lesion size after ablation, thermal dose, and clinical outcome in tcMRgFUS treatment of essential tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Type<\/jats:title><jats:p>Retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Population\/Subjects\/Phantom\/Specimen\/Animal Model<\/jats:title><jats:p>Eight patients with medication\u2010refractory essential tremor were treated using a tcMRgFUS system at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Field Strength\/Sequence<\/jats:title><jats:p>T<jats:sub>2<\/jats:sub>\u2010weighted images were acquired immediately and at 1 year posttreatment at 3T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Assessment<\/jats:title><jats:p>An atlas of the thalamic nuclei and dose maps were warped to the posttreatment images. The thermal dose, the immediate posttreatment lesion volume and 1\u2010year final lesion volume, and the volumes confined inside the ventral division of the ventral lateral posterior thalamic nucleus (VLpv) were correlated to clinical outcome at 1 month and 1 year using Pearson's coefficient. The spatial region of treatment correlating with maximal clinical outcome was derived in a normalized space from average maps of clinical tremor score improvement at 1 year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Statistical Tests<\/jats:title><jats:p>Statistical significance was assessed using the Wilcoxon two\u2010tailed rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The correlations between thermal dose, lesion volume posttreatment and at 1 year, and outcome at 1 year were good (<jats:italic>r<\/jats:italic>\u2009=\u20090.73, 0.65, 0.73, respectively), and were slightly better than at 1 month (<jats:italic>r<\/jats:italic>\u2009=\u20090.57, 0.49, 0.65). Reducing the measurement to include only the portion within the VLpv did not significantly modify the correlations (<jats:italic>P<\/jats:italic>\u2009=\u20090.09). The center of the spatial region of treatment was found in the anterior commissure \u2013 posterior commissure plane, 14.3\u2009mm lateral from the midline, and 8.3\u2009mm rostral to the posterior commissure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Conclusion<\/jats:title><jats:p>In this pilot study a good correlation was found between the size of the lesion, the thermal dose, and the clinical outcome in patients treated for essential tremor with ablation of the VLpv with tcMRgFUS.<\/jats:p><jats:p><jats:bold>Level of Evidence:<\/jats:bold> 1<\/jats:p><jats:p><jats:bold>Technical Efficacy:<\/jats:bold> Stage 4<\/jats:p><jats:p>J. Magn. Reson. Imaging 2017.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmri.25878","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T06:28:38Z","timestamp":1509085718000},"page":"58-65","source":"Crossref","is-referenced-by-count":52,"title":["Transcranial MRI\u2010guided high\u2010intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-6602","authenticated-orcid":false,"given":"Christian","family":"Federau","sequence":"first","affiliation":[{"name":"University of Basle, Division of Diagnostic and Interventional Neuroradiology, Department of Radiology, Petersgraben Basle Switzerland"},{"name":"Stanford University Medical Center, Department of Radiology, Neuroradiology Division Stanford California 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